1996 - 2003年美国短期住院医院出院患者的艰难梭菌感染情况 - Suppr

Clostridium difficile infection in patients discharged from US short-stay hospitals, 1996-2003.

作者信息

McDonald L Clifford, Owings Maria, Jernigan Daniel B

机构信息

Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.

出版信息

Emerg Infect Dis. 2006 Mar;12(3):409-15. doi: 10.3201/eid1205.051064.

US hospital discharges for which Clostridium difficile-associated disease (CDAD) was listed as any diagnosis doubled from 82,000 (95% confidence interval [CI] 71,000-94,000) or 31/100,000 population in 1996 to 178,000 (95% CI 151,000-205,000) or 61/100,000 in 2003; this increase was significant between 2000 and 2003 (slope of linear trend 9.48; 95% CI 6.16-12.80, p = 0.01). The overall rate during this period was severalfold higher in persons >65 years of age (228/100,000) than in the age group with the next highest rate, 45-64 years (40/100,000; p < or = 0.001). CDAD appears to be increasing rapidly in the United States and is disproportionately affecting older persons. Clinicians should be aware of the increasing risk for CDAD and make efforts to control transmission of C. difficile and prevent disease.

美国医院出院病例中，艰难梭菌相关疾病（CDAD）被列为任何诊断的病例数从1996年的82,000例（95%置信区间[CI] 71,000 - 94,000）或每10万人中31例，翻倍至2003年的178,000例（95% CI 151,000 - 205,000）或每10万人中61例；2000年至2003年间这种增加具有统计学意义（线性趋势斜率为9.48；95% CI 6.16 - 12.80，p = 0.01）。在此期间，65岁以上人群的总体发病率（每10万人中228例）比发病率次高的年龄组，即45 - 64岁年龄组（每10万人中40例；p≤0.001）高出数倍。在美国，CDAD似乎正在迅速增加，且对老年人的影响尤为严重。临床医生应意识到CDAD风险的增加，并努力控制艰难梭菌的传播和预防疾病。