Antimicrobial resistance in ribotype 017.

: Antimicrobial resistance (AMR) played an important role in the initial outbreaks of infection (CDI) in the 1970s. ribotype (RT) 017 has emerged as the major strain of in Asia, where antimicrobial use is poorly regulated. This strain has also caused CDI outbreaks around the world for almost 30 years. Many of these outbreaks were associated with clindamycin and fluoroquinolone resistance. AMR and selective pressure is likely to be responsible for the success of this RT and may drive future outbreaks.: This narrative review summarizes the prevalence and mechanisms of AMR in RT 017 and transmission of these AMR mechanisms. To address these topics, reports of outbreaks due to RT 017, epidemiologic studies with antimicrobial susceptibility results, studies on resistance mechanisms found in and related publications available through Pubmed until September 2019 were collated and the findings discussed.: Primary prevention is the key to control CDI. This should be achieved by developing antimicrobial stewardship in medical, veterinary and agricultural practices. AMR is the key factor that drives CDI outbreaks, and methods for the early detection of AMR can facilitate the control of outbreaks.