支架介导的丝裂原活化蛋白激酶信号传导调控与细胞骨架动力学：一种观点
Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspective.
作者信息
Pullikuth Ashok K, Catling Andrew D
机构信息
Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA.
出版信息
Cell Signal. 2007 Aug;19(8):1621-32. doi: 10.1016/j.cellsig.2007.04.012. Epub 2007 May 5.
Abstract
Cell migration is critical for many physiological processes and is often misregulated in developmental disorders and pathological conditions including cancer and neurodegeneration. MAPK signaling and the Rho family of proteins are known regulators of cell migration that exert their influence on cellular cytoskeleton during cell adhesion and migration. Here we review data supporting the view that localized ERK signaling mediated through recently identified scaffold proteins may regulate cell migration.
摘要
细胞迁移对许多生理过程至关重要，并且在发育障碍以及包括癌症和神经退行性变在内的病理状况中常常出现调节异常。丝裂原活化蛋白激酶（MAPK）信号传导和Rho蛋白家族是已知的细胞迁移调节因子，它们在细胞黏附和迁移过程中对细胞骨架发挥作用。在这里，我们综述了支持以下观点的数据：通过最近鉴定出的支架蛋白介导的局部细胞外信号调节激酶（ERK）信号传导可能调节细胞迁移。
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本文引用的文献
1
MEK1 activation by PAK: a novel mechanism.
Cell Signal. 2007 Jul;19(7):1488-96. doi: 10.1016/j.cellsig.2007.01.018. Epub 2007 Jan 24.
2
A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14.
Nat Med. 2007 Jan;13(1):38-45. doi: 10.1038/nm1528. Epub 2006 Dec 31.
3
p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis.
J Cell Biol. 2006 Dec 18;175(6):861-8. doi: 10.1083/jcb.200607025.
4
The RAC binding domain/IRSp53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation.
J Biol Chem. 2006 Nov 17;281(46):35347-58. doi: 10.1074/jbc.M606814200. Epub 2006 Sep 25.
5
Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane.
Mol Biol Cell. 2006 Nov;17(11):4827-36. doi: 10.1091/mbc.e06-02-0132. Epub 2006 Sep 13.
6
Caveolae internalization regulates integrin-dependent signaling pathways.
Cell Cycle. 2006 Oct;5(19):2179-82. doi: 10.4161/cc.5.19.3264. Epub 2006 Oct 1.
7
Rab7 and Rab27a control two motor protein activities involved in melanosomal transport.
Pigment Cell Res. 2006 Oct;19(5):412-23. doi: 10.1111/j.1600-0749.2006.00329.x.
8
The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src.
Mol Cell Biol. 2006 Sep;26(18):6844-58. doi: 10.1128/MCB.00283-06.
9
Phosphorylation of the tubulin-binding protein, stathmin, by Cdk5 and MAP kinases in the brain.
J Neurochem. 2006 Oct;99(1):237-50. doi: 10.1111/j.1471-4159.2006.04113.x. Epub 2006 Aug 21.
10
Endocytic recycling pathways: emerging regulators of cell migration.
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