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脂联素与肾脏疾病进展:另一个流行病学难题?

Adiponectin and renal disease progression: another epidemiologic conundrum?

作者信息

Zoccali C, Mallamaci F

机构信息

Dialisi e Trapianto Renale Ospedali Riuniti, Epidemiologia Clinica e Fisiopatologia delle Malattie Renali e dell'Ipertensione Arteriosa, Reggio Calabria, Italy.

出版信息

Kidney Int. 2007 Jun;71(12):1195-7. doi: 10.1038/sj.ki.5002319.

DOI:10.1038/sj.ki.5002319
PMID:17554349
Abstract

In an analysis based on the Mild to Moderate Kidney Disease (MMKD) study, adiponectin, a pleiotropic, insulin-sensitizing, anti-inflammatory and vasculo-protective cytokine, was directly related to renal disease progression. The precise definition of this apparently paradoxical association now requires that the research focus be moved from the study database to the experimental laboratory.

摘要

在一项基于轻度至中度肾病(MMKD)研究的分析中,脂联素是一种具有多效性、胰岛素增敏、抗炎和血管保护作用的细胞因子,它与肾脏疾病进展直接相关。对于这种明显矛盾的关联的确切定义,现在需要将研究重点从研究数据库转移到实验实验室。

相似文献

1
Adiponectin and renal disease progression: another epidemiologic conundrum?脂联素与肾脏疾病进展:另一个流行病学难题?
Kidney Int. 2007 Jun;71(12):1195-7. doi: 10.1038/sj.ki.5002319.
2
The complex role of adiponectin in chronic kidney disease.脂联素在慢性肾脏病中的复杂作用。
Biochimie. 2012 Oct;94(10):2150-6. doi: 10.1016/j.biochi.2012.02.024. Epub 2012 Mar 2.
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Renal insulin resistance syndrome, adiponectin and cardiovascular events in patients with kidney disease: the mild and moderate kidney disease study.肾病患者的肾胰岛素抵抗综合征、脂联素与心血管事件:轻度和中度肾病研究
J Am Soc Nephrol. 2005 Apr;16(4):1091-8. doi: 10.1681/ASN.2004090742. Epub 2005 Mar 2.
4
Gender-specific association of adiponectin as a predictor of progression of chronic kidney disease: the Mild to Moderate Kidney Disease Study.
Kidney Int. 2007 Jun;71(12):1279-86. doi: 10.1038/sj.ki.5002191. Epub 2007 Apr 25.
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Adiponectin and chronic kidney disease.脂联素与慢性肾脏病
J Ren Nutr. 2007 Jan;17(1):9-12. doi: 10.1053/j.jrn.2006.10.003.
6
Review article: Adiponectin: its role in kidney disease.综述文章:脂联素:其在肾脏疾病中的作用。
Nephrology (Carlton). 2008 Dec;13(6):528-34. doi: 10.1111/j.1440-1797.2008.01018.x.
7
Plasma adiponectin is related to the progression of kidney disease in type 2 diabetes patients.血浆脂联素与 2 型糖尿病患者肾脏疾病的进展有关。
Scand J Clin Lab Invest. 2012 Jul;72(4):333-9. doi: 10.3109/00365513.2012.668928. Epub 2012 Apr 10.
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Adiponectin in renal disease--a review of the evidence as a risk factor for cardiovascular and all-cause mortality.脂联素与肾脏疾病——作为心血管和全因死亡率风险因素的证据综述。
Crit Rev Clin Lab Sci. 2012 Sep-Dec;49(5-6):218-31. doi: 10.3109/10408363.2012.736470. Epub 2012 Dec 6.
9
[The role of leptin, adiponectin and insulin-resistance markers in development of early stages of chronic kidney disease and atherosclerosis of carotid arteries in obese patients].
Ter Arkh. 2011;83(6):47-53.
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The role of adiponectin in metabolic and vascular disease: a review.脂联素在代谢性疾病和血管疾病中的作用:综述
Clin Nephrol. 2011 Jan;75(1):26-33.

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Daily ambient temperature is associated with biomarkers of kidney injury in older Americans.日常环境温度与美国老年人肾脏损伤的生物标志物有关。
Environ Res. 2019 Dec;179(Pt A):108790. doi: 10.1016/j.envres.2019.108790. Epub 2019 Oct 1.
2
Adiponectin is related to markers of endothelial dysfunction and neoangiogenesis in diabetic patients.脂联素与糖尿病患者内皮功能障碍和新生血管生成的标志物有关。
Int Urol Nephrol. 2018 Sep;50(9):1661-1666. doi: 10.1007/s11255-018-1890-1. Epub 2018 May 26.
3
Adipokines and their Relation to Endothelial Dysfunction in Patients with Chronic Kidney Disease.
脂肪因子及其与慢性肾脏病患者内皮功能障碍的关系。
J Clin Diagn Res. 2016 Jan;10(1):BC04-8. doi: 10.7860/JCDR/2016/15867.7060. Epub 2016 Jan 1.
4
Association of Plasma Adiponectin and Oxidized Low-Density Lipoprotein with Carotid Intima-Media Thickness in Diabetic Nephropathy.糖尿病肾病患者血浆脂联素和氧化型低密度脂蛋白与颈动脉内膜中层厚度的关系
J Diabetes Res. 2015;2015:507265. doi: 10.1155/2015/507265. Epub 2015 May 12.
5
Low plasma adiponectin levels predict increased urinary albumin/creatinine ratio in type 2 diabetes patients.血浆脂联素水平低可预测 2 型糖尿病患者尿白蛋白/肌酐比值升高。
Int Urol Nephrol. 2012 Aug;44(4):1151-7. doi: 10.1007/s11255-011-0064-1. Epub 2011 Oct 13.
6
High-calorie diet with moderate protein restriction prevents cachexia and ameliorates oxidative stress, inflammation and proteinuria in experimental chronic kidney disease.高卡路里饮食结合适量蛋白质限制可预防恶病质并改善实验性慢性肾脏病的氧化应激、炎症和蛋白尿。
Clin Exp Nephrol. 2010 Dec;14(6):536-47. doi: 10.1007/s10157-010-0340-x. Epub 2010 Sep 7.
7
The role of novel biomarkers of cardiovascular disease in chronic kidney disease: focus on adiponectin and leptin.心血管疾病新型生物标志物在慢性肾脏病中的作用:聚焦脂联素和瘦素。
Curr Cardiol Rev. 2008 Nov;4(4):287-92. doi: 10.2174/157340308786349516.
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Adiponectin is associated with cardiovascular disease in male renal transplant recipients: baseline results from the LANDMARK 2 study.脂联素与男性肾移植受者的心血管疾病相关:LANDMARK 2 研究的基线结果。
BMC Nephrol. 2009 Oct 12;10:29. doi: 10.1186/1471-2369-10-29.