Allan C A, Strauss B J G, McLachlan R I
Prince Henry's Institute, Clayton, Victoria, Australia.
Int J Impot Res. 2007 Sep-Oct;19(5):448-57. doi: 10.1038/sj.ijir.3901552. Epub 2007 Jun 7.
The ageing process in men is marked by changes in body composition (loss of fat-free mass (FFM) and skeletal muscle, and gain in fat mass (FM)) and is associated with a decline in serum testosterone. Correlations between these aspects of ageing and the acknowledged role of exogenous testosterone in reversing the loss of FFM and gain in FM seen in adult men with congenital or acquired hypoandrogenism have led to the hypothesis that testosterone therapy in ageing men will result in favourable changes in body composition and may improve metabolic status and/or cardiovascular risk. Data from randomized controlled trials of testosterone therapy in ageing men addressing the endpoints of body composition and components of the metabolic syndrome and cardiovascular risk factors are reviewed, and the impact of the increasing prevalence of obesity on these relationships is considered.
男性的衰老过程以身体成分的变化（去脂体重（FFM）和骨骼肌减少，脂肪量（FM）增加）为特征，并且与血清睾酮水平下降有关。衰老的这些方面与外源性睾酮在逆转先天性或后天性雄激素缺乏成年男性中出现的FFM丢失和FM增加方面所公认的作用之间的相关性，引发了这样一种假说，即对老年男性进行睾酮治疗将导致身体成分发生有利变化，并可能改善代谢状况和/或心血管风险。本文综述了针对老年男性身体成分、代谢综合征组成部分和心血管危险因素等终点进行睾酮治疗的随机对照试验数据，并考虑了肥胖患病率上升对这些关系的影响。
