Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, 2525 West End Ave., Nashville, TN, 37203, USA.
Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200031, China.
Maturitas. 2018 Feb;108:77-83. doi: 10.1016/j.maturitas.2017.11.015. Epub 2017 Nov 28.
To examine the associations between anthropometric measurements and functional impairments in a sample of urban elderly Chinese people.
In two population-based cohort studies, the Shanghai Women's Health Study (SWHS) and Shanghai Men's Health Study (SMHS), 11,505 men and 17,166 women aged 70-88 years at the time of the functional assessment were studied. Weight history was collected and anthropometric data were taken at study enrollment (from 1996 to 2000 for the SWHS, 2002-2006 for the SMHS). Information on functional status and current weight was collected at the most recent follow-up survey (from 2011 to 2015). Logistic regression analyses were applied to estimate the associations of body mass index (BMI), waist-hip-ratio (WHR), and weight changes with functional decline.
After a median follow-up of 14.4 years (range 5.4-18.2 years), we found that BMI/WHR at or after middle age, and weight gain during adulthood were significantly associated with impaired walking ability and mental functioning. Being underweight after age 70 was associated with poorer hearing and/or vision as well as poorer memory. The associations between obesity and functional impairment were generally not modified by sex, comorbidity or exercise.
Weight gain, obesity at or after middle age, and underweight after age 70 were associated with physical and mental functional impairments among elderly Chinese people. These findings highlight the importance of maintaining healthy weight to reduce age-related functional decline.
在城市老年中国人样本中，检验人体测量学指标与功能障碍之间的关联。
在两项基于人群的队列研究（上海女性健康研究（SWHS）和上海男性健康研究（SMHS））中，研究了 11505 名男性和 17166 名年龄在 70-88 岁的女性。在功能评估时收集了体重史，并在研究入组时（SWHS 为 1996 年至 2000 年，SMHS 为 2002 年至 2006 年）测量了人体测量学数据。在最近的随访调查中收集了有关功能状态和当前体重的信息（SWHS 为 2011 年至 2015 年，SMHS 为 2013 年至 2017 年）。应用逻辑回归分析来估计 BMI、腰臀比（WHR）和体重变化与功能下降的关联。
在中位随访 14.4 年（范围 5.4-18.2 年）后，我们发现中年及以后的 BMI/WHR 和成年期的体重增加与行走能力和心理功能障碍显著相关。70 岁后体重不足与听力和/或视力较差以及记忆力较差有关。肥胖与功能障碍之间的关联通常不受性别、合并症或运动的影响。
体重增加、中年及以后的肥胖以及 70 岁后体重不足与中国老年人的身体和心理功能障碍有关。这些发现强调了保持健康体重以减少与年龄相关的功能下降的重要性。
