Kasper S M, Dahlmann H, Gerlich W
Institut für Anaesthesiologie und Operative Intensivmedizin, Universität zu Köln.
Anaesthesist. 1991 Nov;40(11):594-601.
The study was designed to evaluate the role of autologous blood transfusion in current clinical practice. METHODS. Standardized questionnaires were distributed to the anesthesia departments of 421 randomly selected hospitals in the 'old' Federal Republic of Germany and West Berlin in August 1989. The questionnaires contained 26 questions relating to (1) the particular hospital, (2) preoperative autologous blood donation (PABD), (3) preoperative plasmapheresis, (4) isovolemic hemodilution, (5) intra- and postoperative autotransfusion, (6) general practice followed in blood transfusion, and (7) blood salvage in children. RESULTS. In all, 207 completed questionnaires (49%) were returned, 12% of which came from university hospitals, 25% from hospitals with more than 500 beds, 58% from hospitals with fewer than 500 beds and 5% from smaller specialized hospitals. Over half (52%) of the responding hospitals were running their own transfusion services or were located in the vicinity of a regional blood bank. The overall proportion of surgical procedures requiring perioperative blood transfusions was 10%. PABD was performed "not at all" in 24% of the hospitals, "rarely" in 28%, "occasionally" in 24%, "frequently" in 10%, and "routinely" in 13%. PABD was standard in 75% of the departments of orthopedic surgery, in 68% of the departments of cardiac surgery, and in 33% of the departments of vascular surgery. In two-thirds of the hospitals reporting the use of PABD, the anesthesia departments were in charge of the autologous blood service. For 64% of the hospitals, liquid storage of whole blood was reported as the standard technique. Patients normally not eligible for homologous blood donation according to established donor criteria were accepted for autologous blood donation at most "occasionally" in 60% of the hospitals, but "frequently" or "mostly" in 36%. Preoperative autologous plasmapheresis was performed when major intraoperative blood loss was anticipated in 12% of the hospitals. Isovolemic hemodilution was performed "not at all" in 30% of the hospitals, "rarely" in 17%, "occasionally" in 25%, "frequently" in 14%, and "mostly" in 12%. The reasons most frequently given for not performing hemodilution were "too time-consuming" (41%) and "too little blood-saving effect" (32%). Autotransfusion devices were available in 40% of the hospitals. Others deemed such devices "badly needed" (5%) or "desirable" (43%), while 45% found them "not necessary." The principal use of intraoperative autotransfusion was in cardiac surgery (79% of the departments), orthopedics (47% of the departments) and vascular surgery (45% of the departments). In 29% of the responding hospitals autotransfusion devices were also used for postoperative autotransfusion ("seldom" in 7%, "occasionally" in 10%, "frequently" in 6%, "mostly" in 6%). In the absence of cardiopulmonary disease, hemoglobin concentrations below 8-10 g/dl were considered an indication for blood transfusion. In patients with compromised cardiopulmonary function the lowest acceptable level was 10-12 g/dl. Blood salvage techniques are obviously rarely used in children. Experiences with PABD in children were reported by 14.5% of the hospitals, experience with isovolemic hemodilution by 22% and with intra- and postoperative autotransfusion in 18% and 12.5% of the hospitals, respectively. Preoperative plasmapheresis was performed in children in 3.5% of the hospitals. CONCLUSIONS. Although the present sample is not representative on a national level, our findings allow the conclusion that the simple techniques of both preoperative autologous blood donation and isovolemic hemodilution are unduly neglected in surgical and anesthetic practice, whereas even smaller hospitals are fairly well equipped with sophisticated autotransfusion devices.
本研究旨在评估自体输血在当前临床实践中的作用。方法:1989年8月,向德意志联邦共和国“旧”州及西柏林随机抽取的421家医院的麻醉科发放标准化问卷。问卷包含26个问题,涉及:(1)具体医院情况;(2)术前自体血捐献(PABD);(3)术前血浆置换;(4)等容血液稀释;(5)术中及术后自体输血;(6)输血的一般做法;(7)儿童血液回收。结果:共收回207份完整问卷(49%),其中12%来自大学医院,25%来自床位超过500张的医院,58%来自床位少于500张的医院,5%来自小型专科医院。超过半数(52%)的回复医院有自己的输血服务部门或位于地区血库附近。需要围手术期输血的外科手术总体比例为10%。24%的医院“完全不”进行PABD,28%“很少”进行,24%“偶尔”进行,10%“经常”进行,13%“常规”进行。75%的骨科手术科室、68%的心脏手术科室以及33%的血管手术科室将PABD作为标准操作。在报告使用PABD的医院中,三分之二的医院麻醉科负责自体血服务。64%的医院报告全血液体储存为标准技术。根据既定献血标准通常不符合异体献血条件的患者,60%的医院最多“偶尔”接受其自体血捐献,但36%的医院“经常”或“大多”接受。12%的医院在预计术中大量失血时进行术前自体血浆置换。30%的医院“完全不”进行等容血液稀释,17%“很少”进行,25%“偶尔”进行,14%“经常”进行,12%“大多”进行。不进行血液稀释最常给出的原因是“太耗时”(41%)和“节省血液效果太差”(32%)。40%的医院有自体输血设备。其他医院认为此类设备“急需”(5%)或“理想”(43%),而45%的医院认为“没必要”。术中自体输血主要用于心脏手术(79%的科室)、骨科(47%的科室)和血管手术(45%的科室)。29%的回复医院也将自体输血设备用于术后自体输血(7%“很少”,10%“偶尔”,6%“经常”,6%“大多”)。在无心肺疾病的情况下,血红蛋白浓度低于8 - 10 g/dl被视为输血指征。对于心肺功能受损的患者,可接受的最低水平为10 - 12 g/dl。血液回收技术在儿童中显然很少使用。14.5%的医院报告有儿童PABD经验,22%的医院有等容血液稀释经验,18%和12.5%的医院分别有术中及术后自体输血经验。3.5%的医院在儿童中进行术前血浆置换。结论:尽管本样本在全国层面不具有代表性,但我们的研究结果表明,术前自体血捐献和等容血液稀释的简单技术在外科和麻醉实践中未得到应有的重视,而即使是较小的医院也配备了相当先进的自体输血设备。