Kuz'min O B, Smirnov P A
Vopr Med Khim. 1975 Jul-Aug;21(4):406-9.
Cyclic 3',5-AMP in vitro increased the activity of Na+, K+-ATPase, isolated from cortex and medulla of rabbit kidney. Maximal stimulating effect was observed in kidney cortex at 10(-6) M concentration and in medulla at 10(-4) M concentration of 3',5'-AMP. Under these conditions the enzymatic activity was increased by 24.6 +/- 4.1% and 27.9 +/- 7.7%, respectively. These data suggest that Na+, K+-ATPase, activated by cyclic 3',5'-AMP, is directly involved in the mechanism of Na+ transport in cells of osmoregulating organs.
环3',5-腺苷酸（cAMP）在体外可提高从兔肾皮质和髓质分离出的钠钾ATP酶（Na⁺, K⁺-ATPase）的活性。在3',5'-腺苷酸浓度为10⁻⁶ M时，兔肾皮质中的钠钾ATP酶活性出现最大刺激效应；在髓质中，该效应出现在3',5'-腺苷酸浓度为10⁻⁴ M时。在此条件下，酶活性分别提高了24.6±4.1%和27.9±7.7%。这些数据表明，由环3',5'-腺苷酸激活的钠钾ATP酶直接参与了渗透调节器官细胞中钠转运的机制。
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