[Association mapping of schizophrenia loci on chromosome 1 by use of pooled DNA genomic screening in eastern Shandong peninsula].
作者信息
Chen Gang, Wen Xiao-yan, Zhu Hai-ning, Wei Ran, Zhou Peng, Luan Meng, Gao Chun-yi, Zhu Jian-ping, Weng Zheng
机构信息
Laboratory of Medical Genetics, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong, 250062 PR China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Jun;24(3):288-92.
OBJECTIVE
To find out association mapping of loci related to schizophrenia on chromosome 1 with microsatellite markers in DNA pooling samples from schizophrenic cases and normal controls in Shandong peninsula.
METHODS
A total of 31 microsatellite markers on chromosome 1 spaced at approximately 10 cM were scanned to two separated DNA pooling samples consisting of 119 schizophrenic cases and 119 normal controls respectively. Statistic analysis was performed by Chi-square test method to compare the difference between the ratio of each allele between the two pooling samples.
RESULTS
Significant statistic difference was found at D1S2878 between cases and controls, and P< 0.01 at this loci.
CONCLUSION
D1S2878 locus on chromosome 1 associates with schizophrenia in Shandong peninsula. Fine mapping and searching for candidate genes are warranted in this region.
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