Chen Gang, Wen Xiao-yan, Zhu Hai-ning, Wei Ran, Zhou Peng, Luan Meng, Gao Chun-yi, Zhu Jian-ping, Weng Zheng
Laboratory of Medical Genetics, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong, 250062 PR China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Jun;24(3):288-92.
To find out association mapping of loci related to schizophrenia on chromosome 1 with microsatellite markers in DNA pooling samples from schizophrenic cases and normal controls in Shandong peninsula.
A total of 31 microsatellite markers on chromosome 1 spaced at approximately 10 cM were scanned to two separated DNA pooling samples consisting of 119 schizophrenic cases and 119 normal controls respectively. Statistic analysis was performed by Chi-square test method to compare the difference between the ratio of each allele between the two pooling samples.
Significant statistic difference was found at D1S2878 between cases and controls, and P< 0.01 at this loci.
D1S2878 locus on chromosome 1 associates with schizophrenia in Shandong peninsula. Fine mapping and searching for candidate genes are warranted in this region.
