Utsuki Satoshi, Oka Hidehiro, Sagiuchi Takao, Fujii Kiyotaka
Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagaw, Japan.
Neurol India. 2007 Apr-Jun;55(2):151-3. doi: 10.4103/0028-3886.32788.
Extraneural metastases of intracranial germinoma are rarely reported. The authors describe the first case of metastatic lung germinoma of the thoracic spine. A 27-year-old man presented with right shoulder pain and right upper limb weakness. He had a history of repetitive radiation therapy - nine (whole-abdomen; 15Gy), 12 (whole brain; 30Gy, whole spine 42Gy) and 14 years ago (local; 32Gy) - for abdominal metastasis, temporal and fourth ventricle metastasis and spinal dissemination and metastatic pineal germinoma, respectively. Magnetic resonance imaging revealed a lung mass invading the thoracic spine that was diagnosed as a germinoma by tumor biopsy. He was treated by irradiation with 54Gy and two cycles of chemotherapy with cisplatin and etoposide. He did not have any sign of tumor eight years later.
颅内生殖细胞瘤的神经外转移鲜有报道。作者描述了首例胸椎转移性肺生殖细胞瘤病例。一名27岁男性因右肩疼痛和右上肢无力就诊。他曾分别因腹部转移、颞叶和第四脑室转移以及脊髓播散和转移性松果体生殖细胞瘤，于9年前（全腹；15Gy）、12年前（全脑；30Gy，全脊柱42Gy）和14年前（局部；32Gy）接受过多次放疗。磁共振成像显示肺部肿块侵犯胸椎，经肿瘤活检诊断为生殖细胞瘤。他接受了54Gy的放疗以及顺铂和依托泊苷的两个周期化疗。8年后他没有任何肿瘤迹象。
