Kunert-Radek J, Pawlikowski M, Stepien H, Janecka A
Institute of Endocrinology, Medical University of Lodz, Poland.
Biochem Biophys Res Commun. 1991 Dec 16;181(2):562-5. doi: 10.1016/0006-291x(91)91226-3.
The effects of thyrotropin releasing hormone (TRH) and of TRH-like tripeptide pGlu-His-Gly-OH (colon mitosis inhibitor, CMI) on spontaneous proliferation of murine splenocytes were investigated in vitro. The 3H-thymidine incorporation into splenocyte DNA was used as an index of proliferation. It was found that TRH suppressed the proliferation of splenocytes. In contrast, CMI was ineffective by itself but used together with TRH blocked the effect of the latter.
在体外研究了促甲状腺激素释放激素（TRH）和类TRH三肽pGlu-His-Gly-OH（结肠有丝分裂抑制剂，CMI）对小鼠脾细胞自发增殖的影响。以3H-胸腺嘧啶核苷掺入脾细胞DNA作为增殖指标。发现TRH抑制脾细胞的增殖。相反，CMI单独使用无效，但与TRH一起使用时可阻断后者的作用。
