Pawlikowski M, Zerek-Mełeń G, Winczyk K
Department of Experimental Endocrinology and Hormone Diagnostics, Medical Academy of Lódź, Poland.
Neuropeptides. 1992 Nov;23(3):199-202. doi: 10.1016/0143-4179(92)90123-e.
The effects of thyroliberin (TRH), a TRH-like tripeptide colon mitosis inhibitor (CMI), a somatostatin analog SMS 201-995 and metoclopramide (dopamine receptor antagonist enhancing prolactin secretion) on rat thymus cell proliferation were investigated. The incorporation of bromodeoxyuridine (BrDU) into thymic cell nuclei was used as an index of the proliferation. It was found that TRH, but not other compounds investigated herein, increased the thymus cell proliferation 12 hours after the injection.
研究了促甲状腺素释放激素（TRH）、一种TRH样三肽结肠有丝分裂抑制剂（CMI）、生长抑素类似物SMS 201-995和甲氧氯普胺（增强催乳素分泌的多巴胺受体拮抗剂）对大鼠胸腺细胞增殖的影响。将溴脱氧尿苷（BrDU）掺入胸腺细胞核作为增殖指标。结果发现，注射后12小时，TRH而非本文研究的其他化合物可增加胸腺细胞增殖。
