用于可烯醇化酮醛对映选择性安息香环化反应的改性手性三唑鎓盐：(+)-苏木酮B的合成
Modified chiral triazolium salts for enantioselective benzoin cyclization of enolizable keto-aldehydes: synthesis of (+)-sappanone B.
作者信息
Takikawa Hiroshi, Suzuki Keisuke
机构信息
Department of Chemistry, Tokyo Institute of Technology, SORST-JST Agency, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8551, Japan.
出版信息
Org Lett. 2007 Jul 5;9(14):2713-6. doi: 10.1021/ol070929p. Epub 2007 Jun 9.
PMID:17559218
Abstract
Asymmetric synthesis of (+)-sappanone B (1), a natural product with a 3-hydroxy chromanone structure, was achieved via enantioselective benzoin cyclization by using a modified Rovis catalyst and triethylamine. This catalyst enabled the successful benzoin cyclization of readily enolizable keto-aldehydes.
摘要
通过使用改良的罗维斯催化剂和三乙胺，经由对映选择性安息香环化反应，实现了具有3-羟基色满酮结构的天然产物(+)-苏木酮B（1）的不对称合成。这种催化剂能够使易于烯醇化的酮醛成功进行安息香环化反应。
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