Vinson Daniel C, Kruse Robin L, Seale J Paul
Department of Family and Community Medicine, University of Missouri-Columbia, Columbia, Missouri 65212, USA.
Alcohol Clin Exp Res. 2007 Aug;31(8):1392-8. doi: 10.1111/j.1530-0277.2007.00440.x. Epub 2007 Jun 9.
Previous work has validated a single question to screen for hazardous or harmful drinking, but identifying those patients who have an alcohol use disorder (AUD) among those who screen positive is still time consuming. We therefore sought to develop and validate a brief assessment instrument using DSM-IV criteria for use in primary care medical practice.
Four cross-sectional surveys of past-year drinkers. The developmental sample included patients presenting to emergency departments with an acute injury. The second sample, from the same study, was recruited by random-digit dialing. The third sample was recruited in 5 family medicine practices in Georgia. The fourth sample was the National Epidemiologic Survey on Alcohol and Related Conditions. Interviews with the first 3 samples used the Diagnostic Interview Schedule. The National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) used the Alcohol Use Disorder and Associated Disabilities Interview Schedule.
Two constructs with promising test characteristics were identified: recurrent drinking in hazardous situations and drinking more than intended. Among those who screened positive with the single question in the developmental sample (N=959), if either of the 2 items was positive, the sensitivity for current AUD was 95% and the specificity was 77%. In the second (N=494) and third (N=280) samples, the sensitivity was 94 and 95% and the specificity was 62 and 66%, respectively, among those with a positive screen. In the NESARC sample, including those with at least 1 occasion in the past year of drinking 5 or more drinks (N=7,890), the sensitivity and specificity were 77 and 86%, respectively.
The sensitivity and specificity of these 2 items across 4 samples suggest that they could be formulated into 2 questions, potentially providing busy primary care clinicians with an efficient, reasonably accurate assessment instrument to identify AUD among those patients who screen positive with the single screening question.
先前的研究已经验证了一个单一问题可用于筛查有害或危险饮酒情况,但在筛查呈阳性的患者中识别出患有酒精使用障碍(AUD)的患者仍然耗时。因此,我们试图开发并验证一种使用《精神疾病诊断与统计手册》第四版(DSM-IV)标准的简短评估工具,用于初级保健医疗实践。
对过去一年饮酒者进行四次横断面调查。发展样本包括因急性损伤就诊于急诊科的患者。来自同一研究的第二个样本通过随机数字拨号招募。第三个样本在佐治亚州的5家家庭医学诊所招募。第四个样本是全国酒精及相关疾病流行病学调查。对前三个样本的访谈使用了诊断访谈表。全国酒精及相关疾病流行病学调查(NESARC)使用了酒精使用障碍及相关残疾访谈表。
识别出两个具有良好测试特征的结构:在危险情况下反复饮酒和饮酒量超过预期。在发展样本中用单一问题筛查呈阳性的患者(N = 959)中,如果这两个项目中的任何一个呈阳性,当前AUD的敏感性为95%,特异性为77%。在第二个样本(N = 494)和第三个样本(N = 280)中,筛查呈阳性者的敏感性分别为94%和95%,特异性分别为62%和66%。在NESARC样本中,包括过去一年中至少有一次饮用5杯或更多酒的人(N = 7890),敏感性和特异性分别为77%和86%。
这两个项目在4个样本中的敏感性和特异性表明,它们可以被制定为两个问题,有可能为忙碌的初级保健临床医生提供一种高效、合理准确的评估工具,以在那些通过单一筛查问题筛查呈阳性的患者中识别AUD。