A novel HLA-B*35 (B*3570) allele of a Caucasian family differing with one amino acid mismatch from HLA-B*3503 allele in exon 4.

A novel HLA-B35 (B3570) allele of a Caucasian family differing with one amino acid mismatch from HLA-B*3503 allele in exon 4.

作者信息

Schlaf G, Erhuma M E, Seliger B, Foell J, Altermann W W

机构信息

Institute of Medical Immunology, Interbranch HLA-Laboratory, Martin Luther University Halle-Wittenberg, Magdeburger Strasse 16, D-06097 Halle, Germany.

出版信息

Tissue Antigens. 2007 Jul;70(1):72-3. doi: 10.1111/j.1399-0039.2007.00845.x.

DOI:10.1111/j.1399-0039.2007.00845.x

PMID:17559587

Abstract

A novel human leucocyte antigen (HLA)-B35 (HLA-B3570) allele has been identified in a Caucasian family from Middle Europe using single allele-specific sequencing strategy. This allele is identical to the HLA-B3503 allele except for one point mutation in exon 4 at codon 188 (CAC-->CGC), resulting in an amino acid change from histidine to arginine.

摘要