通过单倍型特异性测序鉴定一种新的HLA - B等位基因HLA - B*5529。

Identification of a novel HLA-B allele, HLA-B*5529, by haplotype-specific sequencing.

作者信息

Emmerich F, Schönemann C, Galicki L, Salama A

机构信息

Center for Tumor Medicine, Institute for Transfusion Medicine, Charité University Medicine, Berlin, Germany.

出版信息

Tissue Antigens. 2008 May;71(5):486. doi: 10.1111/j.1399-0039.2008.01030.x. Epub 2008 Mar 11.

DOI:10.1111/j.1399-0039.2008.01030.x

PMID:18346031

Abstract

We have identified a novel HLA-B allele, B5529. The novel allele differs from HLA-B5501 by a single nucleotide substitution at codon 479 in exon 3 resulting in an amino acid change from alanine to valine. This alteration neither affects the peptide binding site nor the T-cell receptor (TCR) contact residues. Thus, the newly found allele is estimated to have a low alloreactive potential in case of a mismatch to the most common HLA-B allele B*5501.

摘要

我们鉴定出了一种新的HLA - B等位基因，即B5529。该新等位基因与HLA - B5501的区别在于，第3外显子的密码子479处有一个单核苷酸替换，导致氨基酸从丙氨酸变为缬氨酸。这种改变既不影响肽结合位点，也不影响T细胞受体（TCR）的接触残基。因此，估计新发现的等位基因在与最常见的HLA - B等位基因B*5501不匹配的情况下，具有较低的同种异体反应潜能。