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A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis.
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3
The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity.
Cancer Cell. 2006 Apr;9(4):249-60. doi: 10.1016/j.ccr.2006.03.012.
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Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells.
Curr Opin Hematol. 2006 Jan;13(1):1-6. doi: 10.1097/01.moh.0000190111.85284.8f.
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The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice.
J Clin Invest. 2005 Aug;115(8):2159-68. doi: 10.1172/JCI24225. Epub 2005 Jul 14.
7
Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development.
Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17186-91. doi: 10.1073/pnas.0406702101. Epub 2004 Nov 29.
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E protein silencing by the leukemogenic AML1-ETO fusion protein.
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ETO interacting proteins.
Oncogene. 2004 May 24;23(24):4270-4. doi: 10.1038/sj.onc.1207674.

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