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抗癫痫药物与视觉功能

Antiepileptic drugs and visual function.

作者信息

Verrotti Alberto, Manco Rossella, Matricardi Sara, Franzoni Emilio, Chiarelli Francesco

机构信息

Department of Pediatrics, University of Chieti, Chieti, Italy.

出版信息

Pediatr Neurol. 2007 Jun;36(6):353-60. doi: 10.1016/j.pediatrneurol.2007.03.001.

Abstract

Antiepileptic drugs are known to result in visual disturbances. A number of antiepileptic drugs have recently been reported to result in various abnormalities of vision, particularly deficiencies in visual fields and color vision. Moreover, there has been a marked improvement in the diagnosis and understanding of the pathophysiology of visual disturbance. This review collects evidence for visual adverse effects induced by the older antiepileptic drugs (barbiturates, benzodiazepine, carbamazepine, valproic acid, ethosuximide, and phenytoin) and the newer ones (vigabatrin, topiramate, tiagabine, levetiracetam, lamotrigine, gabapentin, felbamate, and oxcarbazepine).

摘要

已知抗癫痫药物会导致视觉障碍。最近有报道称,多种抗癫痫药物会导致各种视力异常,尤其是视野缺损和色觉异常。此外,在视觉障碍的病理生理学诊断和理解方面有了显著进展。本综述收集了有关 older antiepileptic drugs(巴比妥类、苯二氮卓类、卡马西平、丙戊酸、乙琥胺和苯妥英)以及 newer ones(vigabatrin、托吡酯、噻加宾、左乙拉西坦、拉莫三嗪、加巴喷丁、非氨酯和奥卡西平)引起视觉不良反应的证据。

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