Dewhirst Mark W, Cao Yiting, Li Chuan Yuan, Moeller Benjamin
Duke University Medical Center, Durham, NC 27710, USA.
Radiother Oncol. 2007 Jun;83(3):249-55. doi: 10.1016/j.radonc.2007.05.016. Epub 2007 Jun 8.
The objective of this review is to examine the role that HIF-1 plays in the initiation of angiogenesis and in radiotherapy response. Although these two phenomena may at first seem unrelated, there are parallelisms to be drawn associated with the importance of reactive oxygen species in controlling the transcriptional activity of HIF-1, independently of its main driving force, hypoxia. Knowledge of the mechanisms underlying the control of HIF-1 leads to rationale for its inhibition in a range of clinical scenarios.
本综述的目的是研究缺氧诱导因子-1（HIF-1）在血管生成起始及放疗反应中所起的作用。尽管这两种现象乍一看可能并无关联，但在活性氧物种在控制HIF-1转录活性方面的重要性上存在可类比之处，这与HIF-1的主要驱动因素缺氧无关。了解HIF-1调控的潜在机制为在一系列临床情况下抑制它提供了理论依据。
