过氧化物酶体增殖物激活受体γ（PPARγ）和葡萄糖转运蛋白4（GLUT-4）的表达作为前脂肪细胞分化为脂肪细胞的发育调节因子/标志物。
PPARgamma and GLUT-4 expression as developmental regulators/markers for preadipocyte differentiation into an adipocyte.
作者信息
Fernyhough M E, Okine E, Hausman G, Vierck J L, Dodson M V
机构信息
Department of Animal Sciences, Washington State University, PO Box 646310, Pullman, WA 99164, United States.
出版信息
Domest Anim Endocrinol. 2007 Nov;33(4):367-78. doi: 10.1016/j.domaniend.2007.05.001. Epub 2007 May 29.
In this document, we have integrated knowledge about two major cellular markers found in cells of the adipocyte lineage (an adipogenic marker and a metabolic marker). This review provides information as to how differentiation of a cell (such as an adipofibroblast, fibroblast or preadipocyte) to become a viable (and new) adipocyte is under different regulation than that experienced by an immature adipocyte that is just beginning to accumulate lipid. The differentiation, prior to lipid-filling, involves PPARgamma. Subsequently, lipid-filling of the adipocyte relies on a late subset of genes and, depending on depot specificity, involves GLUT-4 or any number of other metabolic markers.
在本文件中，我们整合了有关在脂肪细胞谱系细胞中发现的两种主要细胞标志物（一种脂肪生成标志物和一种代谢标志物）的知识。本综述提供了关于细胞（如脂肪成纤维细胞、成纤维细胞或前脂肪细胞）分化成为有活力的（新的）脂肪细胞的过程与刚开始积累脂质的未成熟脂肪细胞所经历的调控不同的相关信息。在脂质填充之前的分化过程涉及过氧化物酶体增殖物激活受体γ（PPARγ）。随后，脂肪细胞的脂质填充依赖于一组晚期基因，并且根据储存部位的特异性，涉及葡萄糖转运蛋白4（GLUT-4）或许多其他代谢标志物中的任何一种。
Zotero 插件