Savina Ioulia, Beninger Richard J
Department of Psychology, Queen's University, Kingston ON, Canada, K7L 3N6.
Schizophr Res. 2007 Aug;94(1-3):128-38. doi: 10.1016/j.schres.2007.04.010. Epub 2007 Jun 8.
Theory of mind (ToM), the ability to attribute mental states to others, is associated with medial prefrontal cortical (mPFC) activity and is impaired in schizophrenia. Olanzapine or clozapine but not typical antipsychotics or risperidone preferentially affect c-fos expression in mPFC in animals. We tested the hypothesis that schizophrenic patients treated with different antipsychotics would perform differently on ToM tasks. Groups receiving Typicals (n=23), Clozapine (n=18), Olanzapine (n=20) or Risperidone (n=23) and a Control group of healthy volunteers (n=24) were matched for age, gender, handedness and education. ToM functioning was assessed with picture sequence, second-order belief and faux-pas tests. Schizophrenic groups performed similarly to controls on non-ToM conditions. The Olanzapine and Clozapine groups performed similarly to Controls on ToM tasks. The Typicals and Risperidone groups performed worse than the other groups on ToM tasks. We concluded that ToM performance of schizophrenic patients is influenced by the antipsychotic they are taking. Our results suggest that olanzapine or clozapine but not typicals or risperidone may improve or protect ToM ability.
心理理论（ToM），即将心理状态归因于他人的能力，与内侧前额叶皮质（mPFC）活动相关，且在精神分裂症中受损。奥氮平或氯氮平而非典型抗精神病药物或利培酮会优先影响动物mPFC中的c-fos表达。我们检验了这样一个假设，即接受不同抗精神病药物治疗的精神分裂症患者在心理理论任务上的表现会有所不同。将接受典型抗精神病药物治疗的组（n = 23）、氯氮平组（n = 18）、奥氮平组（n = 20）或利培酮组（n = 23）以及健康志愿者对照组（n = 24）按照年龄、性别、利手和教育程度进行匹配。通过图片序列、二阶信念和失礼测试来评估心理理论功能。在非心理理论条件下，精神分裂症组的表现与对照组相似。在心理理论任务上，奥氮平组和氯氮平组的表现与对照组相似。在心理理论任务上，典型抗精神病药物组和利培酮组的表现比其他组更差。我们得出结论，精神分裂症患者的心理理论表现受其正在服用的抗精神病药物影响。我们的结果表明，奥氮平或氯氮平而非典型抗精神病药物或利培酮可能会改善或保护心理理论能力。
