NAViGO, Grimsby, UK.
CNS Drugs. 2013 May;27(5):335-43. doi: 10.1007/s40263-013-0047-0.
Social cognition is described as the higher mental processes that are engaged while people store, process, and use social information to make sense of themselves and others. Aspects of social cognition include emotion perception, social cue interpretation, attribution style, and theory of mind, all of which appear disordered in schizophrenia. Such social cognitive deficits are believed to be important predictors of functional outcome in schizophrenia, therefore they may represent a crucial treatment target. Few studies have evaluated the influence of antipsychotic treatment on these deficits. The purpose of this review is to examine the relationship between antipsychotic treatment and social cognition, whether antipsychotics improve social cognitive function, and if so to explore differential medication effects. Comprehensive searches of PsycINFO and MEDLINE/PUBMED were conducted to identify relevant published manuscripts. Fifteen relevant papers published in English were found, describing original studies. On the basis of this review, we have drawn the following conclusions: first, the results do not engender optimism for the possibility that antipsychotic drugs can specifically facilitate social recovery. Second, the actions of antipsychotics on social cognition are inconclusive, due to lack of standardization across research groups, leading to inconsistencies between study designs, methods used, and medication dosages. Third, large-scale longitudinal investigations are needed to explore the unclear relationships between social cognition, symptoms, and functional outcome. Other non-pharmacological treatments focusing on training patients in the social cognitive areas may hold more promise.
社会认知被描述为人们在存储、处理和使用社会信息以了解自己和他人时所涉及的更高层次的心理过程。社会认知的各个方面包括情绪感知、社会线索解释、归因风格和心理理论，这些方面在精神分裂症中都存在紊乱。这些社会认知缺陷被认为是精神分裂症功能结果的重要预测因素，因此它们可能代表着一个关键的治疗目标。很少有研究评估抗精神病药物治疗对这些缺陷的影响。本综述的目的是检查抗精神病药物治疗与社会认知之间的关系，抗精神病药物是否改善社会认知功能，如果是，那么探索药物的差异效应。通过对 PsycINFO 和 MEDLINE/PUBMED 进行全面搜索，确定了相关的已发表文献。发现了 15 篇以英文发表的相关论文，描述了原始研究。基于这篇综述，我们得出以下结论：首先，结果并不乐观，认为抗精神病药物可以专门促进社会康复。其次，由于研究小组之间缺乏标准化，导致研究设计、使用的方法和药物剂量之间存在不一致，因此抗精神病药物对社会认知的作用尚不确定。第三，需要进行大规模的纵向研究，以探索社会认知、症状和功能结果之间的不明确关系。其他专注于在社会认知领域训练患者的非药物治疗方法可能更有希望。
