Grande-Allen K J, Osman N, Ballinger M L, Dadlani H, Marasco S, Little P J
Department of Bioengineering, Rice University, Houston, TX 77005, USA.
Cardiovasc Res. 2007 Oct 1;76(1):19-28. doi: 10.1016/j.cardiores.2007.05.014. Epub 2007 May 17.
Calcific aortic valve disease is frequently driven by ageing and the obesity-associated metabolic syndrome, and the increasing impact of these factors indicates that valve disease will become a cardiovascular disease of considerable significance. This disease is now thought to be an active cell-based disease process, which may therefore be amenable to therapeutic intervention. Some similarities are apparent with atherosclerosis. The accumulation of lipid, possibly by retention by proteoglycans and the attraction of inflammatory cells by hyaluronan, may be common to the early stages of both pathologies. The synthesis and structure of glycosaminoglycans, proteoglycans, and hyaluronan are exquisitely regulated, and the signalling pathways controlling these processes may provide tissue-specific opportunities for concomitant prevention of atherosclerosis and calcific aortic valve disease.
钙化性主动脉瓣疾病通常由衰老和肥胖相关的代谢综合征驱动，这些因素日益增加的影响表明瓣膜疾病将成为一种具有相当重要意义的心血管疾病。目前认为这种疾病是一种基于细胞的活跃疾病过程，因此可能适合进行治疗干预。与动脉粥样硬化有一些明显的相似之处。脂质的积累，可能是通过蛋白聚糖的保留以及透明质酸对炎症细胞的吸引，可能是这两种病理早期阶段的共同特征。糖胺聚糖、蛋白聚糖和透明质酸的合成和结构受到精确调控，控制这些过程的信号通路可能为同时预防动脉粥样硬化和钙化性主动脉瓣疾病提供组织特异性的机会。
