Toronto General Research Institute and Department of Pathology, University Health Network, Toronto, Ontario, Canada.
Cardiovasc Pathol. 2011 May-Jun;20(3):183-90. doi: 10.1016/j.carpath.2010.09.008. Epub 2010 Nov 13.
Human heart valve diseases have become an important topic in cardiovascular pathology and medicine. These diseases have different etiologies and manifestations. However, the most common ones including calcific aortic stenosis have histopathological features that are best characterized as a "response to tissue injury" similar to ones seen in numerous tissues and organs. The valve interstitial cell is the prevalent cell type in the valve and is likely the master cell which ultimately regulates cell and molecular repair processes within the valve that involve autocrine and paracrine processes as well as interactions with the matrix components of the valve. This presentation explores the concept of "response to tissue injury" in understanding the pathogenesis of calcific aortic stenosis.
人类心脏瓣膜疾病已成为心血管病理学和医学的重要课题。这些疾病有不同的病因和表现。然而，最常见的疾病包括钙化性主动脉瓣狭窄，其组织病理学特征最符合“组织损伤反应”，类似于许多组织和器官中所见的反应。瓣膜间质细胞是瓣膜中最常见的细胞类型，可能是调节瓣膜内细胞和分子修复过程的主要细胞，这些过程涉及自分泌和旁分泌过程以及与瓣膜基质成分的相互作用。本演讲探讨了“组织损伤反应”的概念，以了解钙化性主动脉瓣狭窄的发病机制。
