Duffin J
Department of Physiology, University of Toronto, Ontario, Canada.
Neuroreport. 1991 Oct;2(10):623-6. doi: 10.1097/00001756-199110000-00018.
A new hypothesis is proposed to explain the generation of respiratory rhythm by the respiratory neurons of the medulla. The basis of the oscillator is a mutual inhibition between early-burst inspiratory, propriobulbar neurons and Bötzinger complex expiratory, bulbospinal neurons, with only the early burst inspiratory neurons possessing adaptive properties. Only one theoretical connection, unsupported by experimental observations, needs to be assumed for this model, that of an inhibitory connection from Bötzinger complex expiratory neurons to early-burst inspiratory neurons. A mathematical simulation of the model was used to test the hypothesis. The oscillating patterns of activity produced by the model were similar to those observed experimentally in these neurons. It is therefore concluded that, based on reasonable assumptions, the proposed hypothesis will produce oscillations similar to those of respiration.
提出了一种新的假说，用以解释延髓呼吸神经元如何产生呼吸节律。振荡器的基础是早期爆发性吸气性、脑桥固有神经元与包钦格复合体呼气性、延髓脊髓神经元之间的相互抑制，只有早期爆发性吸气性神经元具有适应性特性。对于该模型，仅需假定一种理论上的联系（尚无实验观察结果支持），即从包钦格复合体呼气性神经元到早期爆发性吸气性神经元的抑制性联系。利用该模型的数学模拟来检验这一假说。该模型产生的振荡活动模式与在这些神经元中实验观察到的模式相似。因此得出结论，基于合理假设，所提出的假说将产生与呼吸相似的振荡。
