Hirano A, Kochen J A
Acta Neuropathol. 1975 Dec 30;33(4):307-15. doi: 10.1007/BF00686162.
Pellets of lead acetate were implanted into the forebrains of adult rats which were sacrificed at intervals between 4 days and 4 weeks thereafter. Parenchymal necrosis and a number of reactive changes including edema and macrophage invasion were observed. Lead deposits were found in the extracellular spaces and within macrophages but only to a slight extent within glial or meningeal cells. Vascular changes were quite remarkable and included proliferation and the appearance of fenestrated blood vessels as well as some with tubular bodies and striking increases in the number of pinocytotic vesicles.
将醋酸铅颗粒植入成年大鼠的前脑，然后在4天至4周的间隔时间内处死大鼠。观察到实质坏死以及包括水肿和巨噬细胞浸润在内的一些反应性变化。在细胞外间隙和巨噬细胞内发现了铅沉积，但在神经胶质细胞或脑膜细胞内仅发现少量铅沉积。血管变化非常显著，包括血管增生、出现有窗孔的血管以及一些带有管状小体的血管，并且吞饮小泡的数量显著增加。
