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结缔组织对某些重金属的反应。II. 铅：组织学与超微结构

Connective tissue responses to some heavy metals. II. Lead: histology and ultrastructure.

作者信息

Ellender G, Ham K N

出版信息

Br J Exp Pathol. 1987 Jun;68(3):291-307.

PMID:3040063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2013257/
Abstract

Lead loaded ion exchange resin beads implanted into the loose connective tissue of the rat pinna induced local lesions which differed widely from those of the control (sodium loaded) beads (Ellender & Ham 1987). These lesions were characterized by changes in the granulation tissue and the approximating connective tissue. Granulation tissue contained mononuclear phagocytes in various guises, and some cells with intranuclear inclusion bodies. The matrix of the granulation tissue contained collagen fibrils having a wide range of diameters suggestive of altered collagen biosynthesis. Foci of collagen mineralization occurred in zones of combined trauma and lead impregnation. Once mineralized they became enveloped by giant cells and epithelioid cells. Lead in damaged tissues is thought to modify the protective mechanism of calcification inhibition and the biosynthesis of the matrix.

摘要

将负载铅的离子交换树脂珠植入大鼠耳廓的疏松结缔组织中，会引发局部病变，这些病变与对照（负载钠）珠引发的病变有很大差异（埃伦德和哈姆，1987年）。这些病变的特征是肉芽组织和邻近结缔组织发生变化。肉芽组织包含各种形态的单核吞噬细胞，以及一些带有核内包涵体的细胞。肉芽组织基质中含有直径范围广泛的胶原纤维，这表明胶原生物合成发生了改变。胶原矿化灶出现在创伤与铅浸渍合并的区域。一旦矿化，它们就会被巨细胞和上皮样细胞包裹。受损组织中的铅被认为会改变钙化抑制的保护机制和基质的生物合成。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/357a/2013257/d157b8198878/brjexppathol00009-0030-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/357a/2013257/5530fe87d286/brjexppathol00009-0026-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/357a/2013257/c4e8964be055/brjexppathol00009-0027-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/357a/2013257/c58a23d9b96a/brjexppathol00009-0028-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/357a/2013257/7db65a7ae263/brjexppathol00009-0029-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/357a/2013257/b65e4549e5d8/brjexppathol00009-0031-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/357a/2013257/869fefdf316d/brjexppathol00009-0032-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/357a/2013257/bb978238af6b/brjexppathol00009-0033-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/357a/2013257/8ad442b569cb/brjexppathol00009-0034-a.jpg
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引用本文的文献

1
Connective tissue responses to some heavy metals. III. Silver and dietary supplements of ascorbic acid. Histology and ultrastructure.
Br J Exp Pathol. 1989 Feb;70(1):21-39.

本文引用的文献

1
Involvement of macrophages in collagen resorption.巨噬细胞在胶原吸收中的作用。
J Cell Biol. 1969 Apr;41(1):345-54. doi: 10.1083/jcb.41.1.345.
2
Corrosion rate measurements in vivo.体内腐蚀速率测量
J Biomed Mater Res. 1967 Dec;1(4):405-14. doi: 10.1002/jbm.820010405.
3
Lead dosage and the role of the intranuclear inclusion body. An experimental study.铅剂量与核内包涵体的作用。一项实验研究。
Arch Environ Health. 1970 Jun;20(6):705-11. doi: 10.1080/00039896.1970.10665647.
4
The significance of implant shape in experimental testing of biological materials: disc vs. rod.植入物形状在生物材料实验测试中的意义：圆盘形与棒形。
J Biomed Mater Res. 1970 Mar;4(1):1-12. doi: 10.1002/jbm.820040102.
5
Role of macrophages in collagen resorption during hair growth cycle.
J Ultrastruct Res. 1969 Nov;29(3):210-7. doi: 10.1016/s0022-5320(69)90101-4.
6
Considerations on the development of experimental lead encephalopathy.关于实验性铅性脑病发展的思考
Virchows Arch A Pathol Pathol Anat. 1971;352(1):61-74. doi: 10.1007/BF00549764.
7
An international study of "normal" levels of lead in blood and urine.一项关于血液和尿液中铅“正常”水平的国际研究。
Arch Environ Health. 1967 Jul;15(1):60-3. doi: 10.1080/00039896.1967.10664874.
8
Biochemical effects of mercury, cadmium, and lead.汞、镉和铅的生化效应。
Annu Rev Biochem. 1972;41(10):91-128. doi: 10.1146/annurev.bi.41.070172.000515.
9
Phagocytosis of collagen by fibroblasts incident to experimental tooth movement.实验性牙齿移动过程中成纤维细胞对胶原的吞噬作用。
Arch Histol Jpn. 1985 Apr;48(2):149-58. doi: 10.1679/aohc.48.149.
10
Concentration of lead in various endodontic filling materials.各种根管充填材料中的铅浓度。
J Endod. 1976 Jan;2(1):21-4. doi: 10.1016/S0099-2399(76)80027-1.