Barbara L, Baldi F, Longanesi A
Istituto di Clinica Medica e Gastroenterologia, Policlinico S. Orsola, Bologna, Italy.
Ital J Gastroenterol. 1991 Nov;23(8 Suppl 1):36-8.
Irritable bowel syndrome (IBS) is defined as chronic-recurrent abdominal pain in absence of organic lesions. The crucial pathogenetic point is to establish whether pain is related to enhanced sensitivity of the patient or to an abnormal peripheral stimulus originating from the bowel. We can subdivide the patients with abdominal pain into two main groups: the first comprehends those patients with an abnormal response to a normal stimulus (i.e. an enhanced motor response to a meal) (irritable bowel syndrome) and second those patients who have a normal response to an abnormal stimulus (i.e. alimentary factors, laxatives, bile acids) (irritated bowel syndrome). On the basis of our knowledge we can say that the pathogenesis of IBS is complex and not yet completely defined. The crucial point is represented by our capability to discriminate between the "irritable" and "irritated" colon.
肠易激综合征（IBS）被定义为无器质性病变的慢性复发性腹痛。关键的发病机制要点在于确定疼痛是与患者敏感性增强有关，还是与源于肠道的异常外周刺激有关。我们可将腹痛患者分为两大主要组：第一组包括那些对正常刺激有异常反应的患者（即对进食有增强的运动反应）（肠易激综合征），第二组是那些对异常刺激有正常反应的患者（即饮食因素、泻药、胆汁酸）（肠道激惹综合征）。基于我们目前的认知，我们可以说肠易激综合征的发病机制复杂且尚未完全明确。关键在于我们能否区分“易激惹”结肠和“受激惹”结肠。
