Tomas-Ridocci M, Moreno-Osset E, Minguez M, Ballester J, Mora F, Benages A
Digestive Motility Unit, University Clinic Hospital, Valencia, Spain.
Ital J Gastroenterol. 1991 Nov;23(8 Suppl 1):48-52.
The pathogenetic factors involved in the genesis of the irritable bowel syndrome (IBS) has not been fully explained yet. The abnormalities observed in these patients are a hypersensitivity to distension and an amplification of painful sensations. The motor activity of sigmoid colon shows an increased motility index in IBS patients with constipation and a low motility index in those with diarrhea. An hypercaloric meal induces a hypermotility in these patients. In our experience rectal distension evokes abdominal pain in 78% of cases at volumes of 100ml (less than than controls and constipated patients). The perfusion of rectum induces continuous abdominal pain in 89% of IBS patients. We can say that the motility of the whole colon over prolonged periods of time may represent an important progress in understanding the motor function in these patients.
肠易激综合征（IBS）发病机制中涉及的致病因素尚未完全阐明。在这些患者中观察到的异常是对扩张的超敏反应和疼痛感觉的放大。乙状结肠的运动活性在便秘型IBS患者中显示运动指数增加，而在腹泻型患者中则显示运动指数降低。高热量餐会诱发这些患者的运动亢进。根据我们的经验，直肠扩张在100ml容量时可引起78%的病例出现腹痛（少于对照组和便秘患者）。直肠灌注可使89%的IBS患者出现持续性腹痛。我们可以说，长时间内整个结肠的运动可能代表了在理解这些患者运动功能方面的一项重要进展。
