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平面细胞极性:一条还是两条信号通路?

Planar cell polarity: one or two pathways?

作者信息

Lawrence Peter A, Struhl Gary, Casal José

机构信息

Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.

出版信息

Nat Rev Genet. 2007 Jul;8(7):555-63. doi: 10.1038/nrg2125. Epub 2007 Jun 12.

Abstract

In multicellular organisms, cells are polarized in the plane of the epithelial sheet, revealed in some cell types by oriented hairs or cilia. Many of the underlying genes have been identified in Drosophila melanogaster and are conserved in vertebrates. Here we dissect the logic of planar cell polarity (PCP). We review studies of genetic mosaics in adult flies - marked cells of different genotypes help us to understand how polarizing information is generated and how it passes from one cell to another. We argue that the prevailing opinion that planar polarity depends on a single genetic pathway is wrong and conclude that there are (at least) two independently acting processes. This conclusion has major consequences for the PCP field.

摘要

在多细胞生物中,细胞在上皮细胞层平面内呈极化状态,在某些细胞类型中通过定向的毛发或纤毛得以体现。许多相关的基础基因已在黑腹果蝇中被鉴定出来,并且在脊椎动物中是保守的。在此,我们剖析平面细胞极性(PCP)的原理。我们回顾了对成年果蝇基因嵌合体的研究——不同基因型的标记细胞有助于我们理解极化信息是如何产生的以及它是如何从一个细胞传递到另一个细胞的。我们认为,认为平面极性依赖于单一遗传途径的主流观点是错误的,并得出结论:存在(至少)两个独立起作用的过程。这一结论对PCP领域具有重大影响。

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