Kajimoto Yoshinaga, Kuroiwa Toshihiko, Miyatake Shin-Ichi, Ichioka Tsugumichi, Miyashita Minoru, Tanaka Hidekazu, Tsuji Motomu
Departments of'Neurosurgery, Osaka Medical College, Osaka, Japan.
J Neurosurg. 2007 Jun;106(6):1070-4. doi: 10.3171/jns.2007.106.6.1070.
It has been established that fluorescence-guided resection using 5-aminolevulinic acid (5-ALA) is useful in glioma surgery. The authors report on a 65-year-old woman who had a huge atypical left-hemisphere meningioma, which extended into the skull and to the superior sagittal sinus and demonstrated fluorescence in response to administration of 5-ALA. After the tumor was removed, the operative field was observed under the fluorescent mode of a fluorescence surgical microscopy system. Several minute areas of residual tumor tissue were visualized as strong fluorescence behind the vein and sinus, in a part of the hypertrophic dura, and along the edge of the skull. These remnants were completely removed. The authors concluded that fluorescence-guided resection using 5-ALA is useful in cases of atypical meningiomas with a high risk of recurrence.
