用单光子发射计算机断层扫描（SPECT）评估99m锝-六甲基丙烯胺肟（99mTc-HM-PAO）参数以改善对脑病变血流的评估。

Assessment of 99mTc-HM-PAO parameters with SPECT for improved evaluation of blood flow in cerebral lesions.

作者信息

Bartolini A, Gasparetto B, Albano C, Ajmar G, Primavera A, Roncallo F

机构信息

Institute of Clinical Neurology, University of Genoa, Italy.

出版信息

Comput Med Imaging Graph. 1991 Sep-Oct;15(5):303-9. doi: 10.1016/0895-6111(91)90137-k.

DOI:10.1016/0895-6111(91)90137-k

PMID:1756448

Abstract

A method for investigating the linearity between blood flow and distribution of 99mTc-HM-PAO uptake in patients undergoing single photon emission computed tomography (SPECT) is presented. This method, based on particular elaboration techniques of sequential multiple acquisitions, provides a local index: cumulative transit time (CTT) related to all factors, other than blood flow, affecting 99mTc-HM-PAO uptake. Because a correct qualitative blood flow estimation is based on the uniformity of the above factors, the occurrence of a change of this index indicates a nonlinear relation between blood flow and 99mTc-HM-PAO uptake distributions. It was shown that although linearity between blood flow and 99mTc-HM-PAO uptake may be questionable, a qualitative assessment of blood flow was correct in 100% of ischemic patients. In nonischemic patients this percentage fell to 60%.

摘要

本文介绍了一种用于研究接受单光子发射计算机断层扫描（SPECT）的患者血流与99mTc-HM-PAO摄取分布之间线性关系的方法。该方法基于连续多次采集的特定处理技术，提供了一个局部指标：累积通过时间（CTT），它与除血流外影响99mTc-HM-PAO摄取的所有因素相关。由于正确的定性血流估计基于上述因素的一致性，该指标的变化表明血流与99mTc-HM-PAO摄取分布之间存在非线性关系。结果表明，尽管血流与99mTc-HM-PAO摄取之间的线性关系可能存在疑问，但在100%的缺血患者中，血流的定性评估是正确的。在非缺血患者中，这一比例降至60%。