Bartolini A, Gasparetto B, Ruffinengo U, Amore R, Primavera A, Albano C
Institute of Clinical Neurology, University of Genoa CNR-Center of Cerebral Neurophysiology, Italy.
Comput Med Imaging Graph. 1990 Mar-Apr;14(2):91-5. doi: 10.1016/s0895-6111(05)80043-6.
An application of intravenous radionuclide angiography as an adjunct to SPECT with 99mTc HM-PAO is presented. From the angiographic sequence a two-dimensional parametric image is generated computing, pixel by pixel, the center of gravity (COG) of the local time curves. This index is independent of blood flow and reflects the relation between transmitted and extravasated activity. COG value, compared in two symmetrical regions analyzed for differences in flow by SPECT, may help to state whether a detected SPECT changed uptake is linearly related or not to the corresponding change of blood flow. All 23 ischemic patients taken into consideration had a similar backflux in symmetrical regions with conspicuous changed uptake. In 3 meningiomas and 2 arteriovenous angiomas it was possible to detect the occurrence of a changed backflux in the lesion suggesting a nonlinearity between blood flow and 99mTc HM-PAO uptake.
本文介绍了静脉放射性核素血管造影作为99mTc HM-PAO单光子发射计算机断层扫描（SPECT）辅助手段的应用。从血管造影序列中生成二维参数图像，逐像素计算局部时间曲线的重心（COG）。该指标与血流量无关，反映了传输活性与外渗活性之间的关系。通过SPECT分析两个对称区域的血流差异，并比较其COG值，可能有助于判断检测到的SPECT摄取变化是否与相应的血流变化呈线性相关。所有纳入研究的23例缺血性患者在对称区域具有相似的反流，摄取明显改变。在3例脑膜瘤和2例动静脉血管瘤中，有可能检测到病变中反流的改变，提示血流与99mTc HM-PAO摄取之间存在非线性关系。
