Menegaux Florence, Ripert Mahaut, Hémon Denis, Clavel Jacqueline
INSERM, U754, IFR69, and Université Paris-Sud, UMR-S754, Villejuif, France.
Paediatr Perinat Epidemiol. 2007 Jul;21(4):293-9. doi: 10.1111/j.1365-3016.2007.00824.x.
We investigated the role of maternal alcohol and coffee drinking during pregnancy and that of parental smoking in the aetiology of childhood leukaemia. A French, population-based, case-control study was conducted, comparing 472 [407 acute lymphoblastic leukaemia (ALL) and 62 acute myeloblastic leukaemia] cases of childhood acute leukaemia (AL) and 567 population controls, frequency-matched with cases on age, gender and region of residence. Both case and control mothers filled in a comprehensive self-administered standardised questionnaire, eliciting detailed data on maternal alcohol and coffee consumption during pregnancy and parental smoking before, during and after pregnancy. Maternal alcohol consumption of more than 1 drink per day was related to ALL (OR = 2.8 [95% CI 1.8, 5.9]). While maternal coffee consumption was not significantly related to AL (OR = 1.4 [95% CI 0.9, 2.3]), highest intake of coffee (more than 3 cups per day) during pregnancy was associated with AL in children whose mothers were non-smokers (OR = 1.9 [95% CI 1.0, 3.5]). No association with parental smoking, either maternal or paternal, was observed with AL. The present results suggest a possible role of the highest consumption of alcohol by the mother during pregnancy in the aetiology of childhood AL.
我们研究了孕期母亲饮酒和喝咖啡以及父母吸烟在儿童白血病病因学中的作用。开展了一项基于法国人群的病例对照研究，比较了472例儿童急性白血病（AL）病例[407例急性淋巴细胞白血病（ALL）和62例急性髓细胞白血病]和567名人群对照，对照在年龄、性别和居住地区方面与病例进行频数匹配。病例组和对照组的母亲均填写了一份全面的自填式标准化问卷，获取关于孕期母亲饮酒和喝咖啡情况以及父母在孕前、孕期和产后吸烟情况的详细数据。母亲每天饮酒超过1杯与ALL有关（比值比[OR]=2.8[95%置信区间（CI）1.8,5.9]）。虽然母亲喝咖啡与AL无显著关联（OR=1.4[95%CI0.9,2.3]），但孕期咖啡摄入量最高（每天超过3杯）与母亲不吸烟的儿童患AL有关（OR=1.9[95%CI1.0,3.5]）。未观察到父母吸烟（无论是母亲还是父亲）与AL有关联。目前的结果表明孕期母亲饮酒量最高在儿童AL病因学中可能发挥作用。
