Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Environmental epidemiology of Cancer Group, 16, Avenue Paul Vaillant-Couturier, Bâtiment 15/16, 94807, Villejuif, France.
Cancer Causes Control. 2013 Apr;24(4):783-93. doi: 10.1007/s10552-013-0161-9. Epub 2013 Feb 13.
This study aimed to analyze the associations between childhood acute leukemia (AL) and maternal caffeinated beverage consumption during pregnancy, and to explore interactions between caffeinated and alcoholic beverage consumption and polymorphisms of enzymes involved in caffeine and ethanol metabolisms.
The data were generated by the French ESCALE study, which included 764 AL cases and 1,681 controls in 2003-2004. The case and control mothers were interviewed on their consumption habits during pregnancy using a standardized questionnaire. Genotypes of the candidate alleles (NAT25 rs1801280, ADH1C2 rs698 and rs1693482, CYP2E1*5 rs2031920 and rs3813867) were obtained using high-throughput genotyping and imputation data for 493 AL cases and 549 controls with at least two grandparents born in Europe.
Maternal regular coffee consumption during pregnancy was associated with childhood AL (OR = 1.2 [1.0-1.5], p = 0.02); the odds ratios increased linearly with daily intake (p for trend <0.001; >2 cups per day vs. no or less than 1 cup per week: AL: OR = 1.6 [1.2-2.1], lymphoblastic AL: OR = 1.5 [1.1-2.0], myeloblastic AL: OR = 2.4 [1.3-4.3]). The association was slightly more marked for children born to non-smoking mothers. Lymphoblastic AL was also associated with cola soda drinking (OR = 1.3 [1.0-1.5], p = 0.02). No significant gene-environment interactions with coffee, tea, cola soda, or alcohol drinking were observed.
This study provides additional evidence that maternal coffee consumption during pregnancy may be associated with childhood AL. Coffee consumption is a prevalent habit and its potential involvement in childhood AL needs to be considered further.
本研究旨在分析母亲怀孕期间摄入含咖啡因饮料与儿童急性白血病（AL）之间的关联，并探讨咖啡因和乙醇代谢酶的遗传多态性与摄入含咖啡因和含酒精饮料之间的相互作用。
本研究的数据来自法国 ESCALE 研究，该研究于 2003-2004 年纳入了 764 例 AL 病例和 1681 例对照。通过标准化问卷，对病例和对照母亲在怀孕期间的饮食习惯进行了访谈。对于 493 例 AL 病例和 549 例对照（至少有两位在欧洲出生的祖父母），使用高通量基因分型和 imputation 数据，获得了候选等位基因（NAT25 rs1801280、ADH1C2 rs698 和 rs1693482、CYP2E1*5 rs2031920 和 rs3813867）的基因型。
母亲怀孕期间经常喝咖啡与儿童 AL 相关（OR=1.2[1.0-1.5]，p=0.02）；每日摄入量与患病风险呈线性关系（趋势检验 p<0.001；每天饮用>2 杯 vs. 每周饮用不到 1 杯或不饮用：AL：OR=1.6[1.2-2.1]，淋巴母细胞性 AL：OR=1.5[1.1-2.0]，髓母细胞性 AL：OR=2.4[1.3-4.3]）。对于不吸烟母亲所生的孩子，这种关联更为明显。淋巴母细胞性 AL 也与饮用可乐汽水有关（OR=1.3[1.0-1.5]，p=0.02）。未观察到咖啡、茶、可乐苏打水或饮酒与基因-环境之间的显著相互作用。
本研究提供了额外的证据，表明母亲怀孕期间摄入咖啡可能与儿童 AL 有关。咖啡是一种普遍的饮食习惯，需要进一步考虑其在儿童 AL 中的潜在作用。
