Tayama J, Sagami Y, Shimada Y, Hongo M, Fukudo S
Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Neurogastroenterol Motil. 2007 Jun;19(6):471-83. doi: 10.1111/j.1365-2982.2007.00903.x.
Patients with irritable bowel syndrome (IBS) may have a higher tone of corticotropin-releasing hormone (CRH) in the brain. We tested our hypothesis that peripheral administration of CRH antagonist, alpha-helical CRH(9-41) (alphahCRH), improves decreased alpha power spectra and increased beta power spectra of electroencephalogram (EEG) in IBS patients. A barostat bag was inserted to the descending colon of 10 normal controls and 10 IBS patients. The EEG power spectra and topography were measured during baseline period and colonic distention period with the administration of saline followed by the administration of 10 microg kg(-1) of alphahCRH. IBS patients showed a significantly lower alpha power percentage and a higher beta power percentage than normal controls during baseline. Colonic distention induced a decrease in the alpha power percentage and an increase in the beta power percentage in both groups without difference between groups. After the administration of alphahCRH, changes in the EEG power spectra in response to colonic distention were blunted and the differences in the EEG power spectra between IBS patients and controls vanished. Peripheral administration of alphahCRH almost normalized EEG activities in IBS patients. Our data strongly suggest that CRH plays an important role in IBS.
肠易激综合征（IBS）患者大脑中的促肾上腺皮质激素释放激素（CRH）水平可能较高。我们检验了这样一个假设：外周给予CRH拮抗剂α-螺旋CRH(9-41)（alphahCRH）可改善IBS患者脑电图（EEG）中α功率谱降低和β功率谱升高的情况。将一个压力调节袋插入10名正常对照者和10名IBS患者的降结肠。在基线期和结肠扩张期测量EEG功率谱和地形图，先给予生理盐水，随后给予10μg kg(-1)的alphahCRH。在基线期，IBS患者的α功率百分比显著低于正常对照者，而β功率百分比则高于正常对照者。结肠扩张导致两组患者的α功率百分比下降，β功率百分比升高，两组之间无差异。给予alphahCRH后，结肠扩张引起的EEG功率谱变化减弱，IBS患者与对照者之间的EEG功率谱差异消失。外周给予alphahCRH几乎使IBS患者的EEG活动恢复正常。我们的数据强烈表明，CRH在IBS中起重要作用。
