Lelic Dina, Olesen Søren Schou, Graversen Carina, Brock Christina, Valeriani Massimiliano, Drewes Asbjørn Mohr
Dina Lelic, Søren Schou Olesen, Carina Graversen, Christina Brock, Asbjørn Mohr Drewes, Mech-Sense, Department of Gastroenterology and Hepatology, Mølleparkvej 4, Aalborg University Hospital, 9000 Aalborg, Denmark.
World J Gastrointest Pathophysiol. 2014 Feb 15;5(1):33-9. doi: 10.4291/wjgp.v5.i1.33.
Intense abdominal pain is the most common symptom in chronic pancreatitis, but the underlying mechanisms are not completely understood and pain management remains a significant clinical challenge. The focus of pain origin in chronic pancreatitis traditionally has been on the pancreatic gland, assuming pain to originate in the pancreas or its surrounding organs. However, research in the last decade points to abnormal central nervous system pain processing. For this reason, electroencephalography has been receiving increasing attention. In contrast to imaging methods such as functional magnetic resonance imaging and positron emission tomography, electroencephalogram has excellent temporal resolution making it possible to investigate central processing of pain on a millisecond time scale. Moreover, continuously advancing methodology made it possible to explore brain sources responsible for generation of evoked potentials and hence to study brain reorganization due to pain in chronic pancreatitis. The aim of this review is to give an overview of the current methods and findings in electroencephalography as a tool to unravel the origin of pancreatic pain.
剧烈腹痛是慢性胰腺炎最常见的症状，但其潜在机制尚未完全明确，疼痛管理仍是一项重大的临床挑战。传统上，慢性胰腺炎疼痛的起源一直聚焦于胰腺，认为疼痛源自胰腺或其周围器官。然而，过去十年的研究表明中枢神经系统疼痛处理存在异常。因此，脑电图检查越来越受到关注。与功能磁共振成像和正电子发射断层扫描等成像方法不同，脑电图具有出色的时间分辨率，能够在毫秒时间尺度上研究疼痛的中枢处理过程。此外，不断发展的方法使得探索诱发电位产生的脑源成为可能，从而研究慢性胰腺炎疼痛导致的大脑重组。这篇综述的目的是概述脑电图作为揭示胰腺疼痛起源工具的当前方法和研究结果。
