Zöllei Eva, Csillik Andrea, Rabi Sándor, Gingl Zoltán, Rudas László
Medical Intensive Care Unit, Department of Anaesthesiology and Intensive Care, University of Szeged, Szeged, Hungary.
Clin Physiol Funct Imaging. 2007 Jul;27(4):205-10. doi: 10.1111/j.1475-097X.2007.00736.x.
The aim of this study was to assess the influence of breathing pattern on the reproducibility of the most commonly used heart rate and blood pressure variability parameters and baroreflex indices. 5-5 min ECG and blood pressure recordings were made and repeated for 10 healthy volunteers in supine rest on 10 consecutive days during spontaneous and 6 min(-1) patterned breathing. We investigated the following parameters: mean RR interval (RRI); the standard deviation of RR intervals (SDRR); the root mean square of successive differences in RRI (RMSSD); the percentage of RRIs which differed by 50% from the proceeding RRI (PNN50); mean systolic arterial pressure (SAP); the standard deviation of SAP (SAP SD); mean mean arterial pressure (MAP); mean diastolic blood pressure (DAP) and baroreflex indices from spontaneous sequence method (upBRS and downBRS) and from cross spectral analysis (LF alpha, HF alpha). To assess reproducibility for each parameter within- and between-subject variability values were calculated and the ratio of within- and between-subject variability was assessed. In addition, we calculated intraclass correlation coefficient (ICC). Compared to spontaneous respiration during 6 min(-1) patterned breathing the heart rate and blood pressure variability increased; upBRS, LF alpha and HF alpha increased, downBRS did not change. However, ICC showed good reproducibility for most parameters, which did not improve further with controlled breathing. In conclusion, respiration had a strong influence on the most widely used cardiovascular autonomic parameters. The controlling of breathing did not result in consistent improvement in their reproducibility.
本研究旨在评估呼吸模式对最常用的心率和血压变异性参数以及压力反射指数再现性的影响。对10名健康志愿者连续10天在仰卧休息时进行5 - 5分钟的心电图和血压记录，记录在自然呼吸和6次/分钟的模式化呼吸过程中进行重复。我们研究了以下参数：平均RR间期（RRI）；RR间期的标准差（SDRR）；RR间期逐次差值的均方根（RMSSD）；与前一个RR间期相差50%的RR间期百分比（PNN50）；平均收缩动脉压（SAP）；SAP的标准差（SAP SD）；平均平均动脉压（MAP）；平均舒张压（DAP）以及来自自然序列法（upBRS和downBRS）和交叉谱分析（LF alpha、HF alpha）的压力反射指数。为了评估每个参数的再现性，计算了受试者内和受试者间的变异性值，并评估了受试者内和受试者间变异性的比率。此外，我们计算了组内相关系数（ICC）。与6次/分钟模式化呼吸期间的自然呼吸相比，心率和血压变异性增加；upBRS、LF alpha和HF alpha增加，downBRS没有变化。然而，ICC显示大多数参数具有良好的再现性，在控制呼吸时并没有进一步改善。总之，呼吸对最广泛使用的心血管自主参数有很大影响。控制呼吸并没有导致其再现性的一致改善。
