Translocation (8;21) in acute nonlymphocytic leukemia delineated by chromosomal in situ suppression hybridization.

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作者信息

Popp S, Jauch A, Qiu J Y, Smialek B, Cremer T, Becher R

机构信息

Innere Universitätsklinik (Tumorforschung), West German Cancer Center Essen.

出版信息

Cancer Genet Cytogenet. 1991 Nov;57(1):103-7. doi: 10.1016/0165-4608(91)90195-z.

DOI:10.1016/0165-4608(91)90195-z

PMID:1756476

Abstract

In situ suppression hybridization with recombinant bacteriophage DNA libraries for chromosomes 8 and 21 was performed in two cases of acute nonlymphocytic leukemia, type FAB M2. In both cases, cytogenetic analysis by conventional G-banding revealed t(8;21)(q22;q22). In situ suppression hybridization was able to prove the reciprocal nature of the translocation in both cases by identifying the terminal end of chromosome 21 translocated to the derivative chromosome 8q-.

摘要

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