Translocation (8;12;21)(q22.1;q24.1;q22.1): a new masked type of t(8;21)(q22;q22) in a patient with acute myeloid leukemia.

作者信息

Saitoh K, Miura I, Ohshima A, Takahashi N, Kume M, Utsumi S, Kobayashi Y, Hashimoto K, Hatano Y, Nimura T, Saito M, Enomoto K, Ohhira M, Shimizu K, Ohki M, Miura A B

机构信息

Third Department of Internal Medicine, Akita University School of Medicine, Japan.

出版信息

Cancer Genet Cytogenet. 1997 Jul 15;96(2):111-4. doi: 10.1016/s0165-4608(96)00320-2.

The translocation t(8;21)(q22;q22) is found in 40% of cases of acute myeloid leukemia (AML) designated as the subtype M2 in the French-American-British (FAB) classification. The 8;21 translocation is clinically of interest because patients with this subtype have a good prognosis. We describe a masked type of the translocation, t(8;12;21)(q22.1;q24.1;q22.1). The translocation was first interpreted as t(8;12)(q22;q24) based on cytogenetics, but was reevaluated as a result of Southern blot and fluorescence in situ hybridization (FISH) analyses.