Meuret Alicia E, Ritz Thomas, Wilhelm Frank H, Roth Walton T
Department of Psychology, Southern Methodist University, Dallas, TX 75205, USA.
Appl Psychophysiol Biofeedback. 2007 Jun;32(2):99-109. doi: 10.1007/s10484-007-9036-8. Epub 2007 Jun 13.
This pilot study aimed to evaluate the feasibility and potential benefits of a novel biofeedback breathing training for achieving sustained increases in pCO(2) levels.
Twelve asthma patients were randomly assigned to an immediate 4-week treatment group or waiting list control. Patients were instructed to modify their respiration in order to change levels of end-tidal pCO(2) using a hand-held capnometer. Treatment outcome was assessed in frequency and distress of symptoms, asthma control, lung function, and variability of peak expiratory flow (PEF).
We found stable increases in pCO(2) and reductions in respiration rate during treatment and 2-month follow-up. Mean pCO(2) levels rose from a hypocapnic to a normocapnic range at follow-up. Frequency and distress of symptoms was reduced and reported asthma control increased. In addition, mean PEF variability decreased significantly in the treatment group.
Our pilot intervention provided evidence for the feasibility of pCO(2)-biofeedback training in asthma patients.
本初步研究旨在评估一种新型生物反馈呼吸训练对于实现动脉血二氧化碳分压（pCO₂）水平持续升高的可行性及潜在益处。
12名哮喘患者被随机分配至立即接受为期4周治疗的治疗组或等待名单对照组。指导患者使用手持式二氧化碳监测仪调整呼吸，以改变呼气末二氧化碳分压水平。通过症状的频率和严重程度、哮喘控制情况、肺功能以及呼气峰值流速（PEF）的变异性来评估治疗效果。
我们发现治疗期间及2个月随访期内，pCO₂水平稳定升高，呼吸频率降低。随访时，平均pCO₂水平从低碳酸血症范围升至正常碳酸血症范围。症状的频率和严重程度降低，报告的哮喘控制情况改善。此外，治疗组的平均PEF变异性显著降低。
我们的初步干预为pCO₂生物反馈训练在哮喘患者中的可行性提供了证据。
