Faragian Sarit, Kurs Rena, Poyurovsky Michael
Research Unit, Tirat Carmel Mental Health Center, POB 9, Tirat Carmel 30200, Israel.
Child Psychiatry Hum Dev. 2008 Mar;39(1):39-48. doi: 10.1007/s10578-007-0069-2. Epub 2007 Jun 13.
A substantial proportion of adolescent schizophrenia patients also has obsessive-compulsive disorder (OCD). As the reliability of OCD identification in schizophrenia has been challenged, we evaluated insight into OCD symptoms and awareness of schizophrenia, using the Brown Assessment of Beliefs Scale and the Scale to Assess Unawareness of Mental Disorder respectively, in 22 adolescent inpatients who met DSM-IV criteria for both schizophrenia and OCD. Awareness of illness was also assessed in a comparison group of 22 non-OCD adolescent schizophrenia patients. Nineteen (86.3%) schizo-obsessive patients exhibited good or fair insight into OCD, while only 3 patients revealed lack of insight. Roughly 30% of patients in the two schizophrenia groups with and without OCD exhibited unawareness of schizophrenia, indicating that the presence of OCD does not substantially modify global awareness of illness. The effect size of the correlation between insight into OCD and awareness of schizophrenia in the schizo-obsessive group was small and not statistically significant. Our findings support the notion that OCD in adolescent schizophrenia patients represent an identifiable dimension of psychopathology independent of core schizophrenia symptoms. Early identification of this potentially treatable syndrome is imperative for appropriate diagnosis and treatment of this unique subset of schizophrenia patients.
相当一部分青少年精神分裂症患者还患有强迫症(OCD)。由于精神分裂症中强迫症识别的可靠性受到了挑战,我们分别使用布朗信念评估量表和精神障碍无自知力评估量表,对22名符合精神分裂症和强迫症DSM-IV标准的青少年住院患者的强迫症症状自知力和精神分裂症自知力进行了评估。在一个由22名无强迫症的青少年精神分裂症患者组成的对照组中也评估了疾病自知力。19名(86.3%)精神分裂症合并强迫症患者对强迫症表现出良好或尚可的自知力,而只有3名患者自知力缺乏。在有和没有强迫症的两个精神分裂症组中,约30%的患者表现出对精神分裂症缺乏自知力,这表明强迫症的存在并没有实质性改变整体疾病自知力。精神分裂症合并强迫症组中对强迫症的自知力与对精神分裂症的自知力之间的相关性效应量较小且无统计学意义。我们的研究结果支持这样一种观点,即青少年精神分裂症患者的强迫症代表了一种可识别的精神病理学维度,独立于精神分裂症的核心症状。早期识别这种潜在可治疗的综合征对于准确诊断和治疗这一独特的精神分裂症患者亚组至关重要。