Pamukkale University Medicine Faculty, Psychiatry Department, Doktorlar Cd, 20100 Denizli, Turkey.
Eur Psychiatry. 2012 Apr;27(3):192-9. doi: 10.1016/j.eurpsy.2010.03.005. Epub 2010 Jun 9.
Obsessive compulsive symptoms are more frequent in patients with schizophrenia compared to normal population. Patients with obsessive compulsive disorder may also exhibit psychosis-like symptoms. Based on these findings, it has been suggested that there is a spectrum of disorders between OCD and schizophrenia. We compared two OCD groups (with good and poor insight) and two schizophrenia groups (with and without OCD) in this recommended spectrum especially in terms of neurological soft signs (NSSs) associated with sensory integration. The schizophrenia with OCD (schizo-obsessive) group exhibited worse performance than the schizophrenia group (p=0.002) in only graphesthesia tasks. Moreover, schizo-obsessive patients exhibited worse performance compared to OCD patients in terms of graphesthesia (p=0.001) and audiovisual integration (p=0.001). Interestingly, OCD patients with poor insight tended to exhibit graphesthesia deficit in a similar manner to schizo-obsessive patients rather than OCD patients. According to our results, graphesthesia disorder is strongly associated both with OCD and schizophrenia. This suggests that neurodevelopmental disorders that lead to graphesthesia disorder overlap in comorbid OCD and schizophrenia patients.
与正常人群相比，精神分裂症患者的强迫症症状更为频繁。强迫症患者也可能表现出类似精神病的症状。基于这些发现，有人认为强迫症和精神分裂症之间存在一系列障碍。我们在这个推荐的谱系中比较了两组强迫症患者（洞察力良好和不佳）和两组精神分裂症患者（伴或不伴强迫症），特别是在与感觉整合相关的神经软体征（NSS）方面。在只有手写感觉任务中，伴有强迫症的精神分裂症（精神分裂强迫）组的表现比精神分裂症组差（p=0.002）。此外，与强迫症患者相比，精神分裂强迫患者在手写感觉（p=0.001）和视听整合（p=0.001）方面的表现更差。有趣的是，洞察力不佳的强迫症患者在手写感觉方面的表现与精神分裂强迫患者相似，而不是与强迫症患者相似。根据我们的结果，手写感觉障碍与强迫症和精神分裂症都有很强的关联。这表明导致手写感觉障碍的神经发育障碍在伴有强迫症和精神分裂症的共病患者中重叠。
