Molecular cytogenetic analysis of a medulloblastoma with isochromosome 17 and double minutes.

作者信息

Sawyer J R, Swanson C M, Roloson G J, Longee D C, Boop F A, Chadduck W M

机构信息

Department of Pathology, University of Arkansas for Medical Sciences, Little Rock.

出版信息

Cancer Genet Cytogenet. 1991 Dec;57(2):181-6. doi: 10.1016/0165-4608(91)90150-s.

Cytogenetic analysis of a medulloblastoma revealed two abnormal cell lines of 48,XY, +8, +8, -14, +der(14)t(1;14)(q11;p11),i(17q) and 51,XY, +5, +6, +8, +8, -14 + 20, +der (14)t(1;14)(q11;p11),i(17q), + dmin. The finding of double minute chromosomes in some medulloblastomas has been associated with amplification of the c-myc or N-myc oncogenes. We were unable to detect gene amplification with these probes by Southern blot analysis.