Stuart A G, Pearson A D, Emslie J, Lennard A, Davison E V, Perry R H, Crawford P J
Department of Child Health, University of Newcastle Upon Tyne, England.
Med Pediatr Oncol. 1993;21(4):295-8. doi: 10.1002/mpo.2950210412.
A 3-year-old girl developed central nervous system, bone and bone marrow metastases, and hypercalcaemia shortly after presentation with medulloblastoma. Cytogenetic studies of the involved bone marrow showed multiple abnormalities including iso(17q). This chromosome rearrangement has been reported in other cases of recurrent or disseminated medulloblastoma. More studies are required relating the karyotypes of medulloblastomas to long-term outcome to determine if the presence of iso(17q) is a prognostic factor in this malignancy.
一名3岁女孩在髓母细胞瘤发病后不久出现中枢神经系统、骨骼和骨髓转移以及高钙血症。对受累骨髓进行的细胞遗传学研究显示出多种异常，包括等臂（17q）。这种染色体重排在其他复发性或播散性髓母细胞瘤病例中已有报道。需要开展更多研究，将髓母细胞瘤的核型与长期预后相关联，以确定等臂（17q）的存在是否是这种恶性肿瘤的一个预后因素。
