Meijers M, van Garderen-Hoetmer A, Lamers C B, Rovati L C, Jansen J B, Woutersen R A
Department of Biological Toxicology, TNO Toxicology and Nutrition Institute, Zeist, The Netherlands.
Cancer Lett. 1991 Dec 1;60(3):205-11. doi: 10.1016/0304-3835(91)90115-x.
Trypsin inhibitors have been shown to promote pancreatic growth as well as the development of pancreatic tumours in rats. The present study was carried out to examine the effects of the synthetic trypsin inhibitor camostate on the growth of the pancreas and on the development of pancreatic preneoplastic and neoplastic lesions in hamsters treated with N-nitrosobis(2-oxopropyl)amine. A specific cholecystokinin-receptor antagonist was administered to determine the role of cholecystokinin in camostate action. The animals were killed 19 weeks after the first injection with N-nitrosobis(2-oxopropyl)amine. Camostate caused an increase in growth of the pancreas and a decrease in the number of (pre)neoplastic ductular pancreatic lesions. Lorglumide (CR-1409) did not influence these effects of camostate. It was concluded that rats and hamsters behave differently with regard to the effect of camostate on pancreatic growth and carcinogenesis.
已证实胰蛋白酶抑制剂可促进大鼠胰腺生长以及胰腺肿瘤的发展。本研究旨在探讨合成胰蛋白酶抑制剂卡莫司他对用N-亚硝基双（2-氧代丙基）胺处理的仓鼠胰腺生长以及胰腺肿瘤前和肿瘤性病变发展的影响。给予一种特异性胆囊收缩素受体拮抗剂以确定胆囊收缩素在卡莫司他作用中的作用。在首次注射N-亚硝基双（2-氧代丙基）胺后19周处死动物。卡莫司他导致胰腺生长增加，（肿瘤前）胰腺导管性病变数量减少。洛谷胺（CR-1409）不影响卡莫司他的这些作用。得出的结论是，在卡莫司他对胰腺生长和致癌作用的影响方面，大鼠和仓鼠的表现不同。
