胆囊收缩素在仓鼠中由蛙皮素诱导的胰腺病变发展过程中的作用。

Role of cholecystokinin in the development of BOP-induced pancreatic lesions in hamsters.

作者信息

Meijers M, van Garderen-Hoetmer A, Lamers C B, Rovati L C, Jansen J B, Woutersen R A

机构信息

Department of Biological Toxicology, TNO-CIVO Toxicology and Nutrition Institute, Zeist, The Netherlands.

出版信息

Carcinogenesis. 1990 Dec;11(12):2223-6. doi: 10.1093/carcin/11.12.2223.

DOI:10.1093/carcin/11.12.2223

PMID:2265473

Abstract

Cholecystokinin (CCK) has been shown to promote pancreatic growth and azaserine-induced pancreatic carcinogenesis in rats. The present study was carried out to determine effects of CCK on pancreatic growth and carcinogenesis in the N-nitrosobis(2-oxopropyl)amine (BOP) hamster model. One hundred male Syrian golden hamsters were injected s.c. once weekly with 20 mg BOP/kg body wt at 6, 7 and 8 weeks of age, and divided into four groups of 25 animals each, which received one of the following treatments (once daily, 3 days/week for 16 weeks): gelatin; CR-1409, a potent CCK-receptor antagonist; CCK-8, 2.5 micrograms/kg body wt; or CCK-8 in combination with CR-1409 (30 min before CCK treatment). The animals were killed after 19 weeks. The growth of the pancreas but not the incidence of pancreatic (pre)neoplastic lesions was enhanced by CCK-8. CR-1409 did not influence the effect of CCK on pancreatic growth.

摘要

胆囊收缩素（CCK）已被证明可促进大鼠胰腺生长及氮杂丝氨酸诱导的胰腺癌发生。本研究旨在确定CCK对N-亚硝基双（2-氧代丙基）胺（BOP）仓鼠模型中胰腺生长和癌变的影响。100只雄性叙利亚金仓鼠在6、7和8周龄时每周皮下注射一次20 mg BOP/kg体重，然后分为四组，每组25只动物，分别接受以下治疗之一（每天一次，每周3天，共16周）：明胶；强效CCK受体拮抗剂CR-1409；2.5微克/千克体重的CCK-8；或CCK-8与CR-1409联合使用（在CCK治疗前30分钟）。19周后处死动物。CCK-8可促进胰腺生长，但不影响胰腺（癌）前病变的发生率。CR-1409不影响CCK对胰腺生长的作用。