Kanamori Noriaki, Fujii Masashi, Kochi Mitsugu, Kaiga Teruo, Takahashi Tohru, Takayama Tadatoshi
Digestive Surgery, Nihon University School of Medicine.
Gan To Kagaku Ryoho. 2007 Jun;34(6):881-4.
We performed in vivo chemosensitivity tests on human gastric carcinoma. To evaluate the efficacy of some combined chemotherapy for human gastric carcinoma maintained in the subcutaneous space in nude mice, we designed the following six experimental groups: 1) 5-FU group, 2) CDDP group, 3) CPT-11 group, 4) combined therapy group of 5-FU and CDDP, 5) combined therapy group of 5-FU and CPT-11, and 6) combined therapy group of CPT-11 and CDDP. An in vivo nude mice assay was performed. Histopathological changes of the tumors in nude mice, treated with anti-cancer agents,were also evaluated and compared to the results of the nude mice assay. Based on histopathological grading,the true positive rate of the nude mice assay was 0%, the true negative rate was 83.3%, and the accuracy rate was 83.3%. CPT-11 appeared to be highly efficacious when given in combination with CDDP in human gastric cancer cell lines. These results suggest that combination chemotherapy with CPT-11 and CDDP is clinically effective for gastric cancer patients.
我们对人胃癌进行了体内化学敏感性测试。为评估在裸鼠皮下维持生长的人胃癌的某些联合化疗的疗效，我们设计了以下六个实验组：1）5-氟尿嘧啶组，2）顺铂组，3）伊立替康组，4）5-氟尿嘧啶和顺铂联合治疗组，5）5-氟尿嘧啶和伊立替康联合治疗组，以及6）伊立替康和顺铂联合治疗组。进行了体内裸鼠实验。还评估了用抗癌药物治疗的裸鼠肿瘤的组织病理学变化，并与裸鼠实验结果进行比较。基于组织病理学分级，裸鼠实验的真阳性率为0%，真阴性率为83.3%，准确率为83.3%。在人胃癌细胞系中，伊立替康与顺铂联合使用时似乎具有高效性。这些结果表明，伊立替康和顺铂联合化疗对胃癌患者具有临床疗效。
