胎盘早剥时蜕膜中RCAS1的免疫反应性：免疫细胞的存在及活性
RCAS1 decidual immunoreactivity during placental abruption: immune cell presence and activity.
作者信息
Wicherek Lukasz, Galazka Krystyna, Lazar Agata
机构信息
Department of Gynecology and Oncology, Jagiellonian University, Krakow, Poland.
出版信息
Am J Reprod Immunol. 2007 Jul;58(1):46-55. doi: 10.1111/j.1600-0897.2007.00490.x.
PROBLEM
RCAS1 is a protein responsible for the suppression of cytotoxic immune response during gestation. The present study evaluates the immunoreactivity level of RCAS1 with respect to immune cell status during placental abruption (PA) and retained placental tissue (RPT).
METHOD OF STUDY
RCAS1, CD3, CD56, CD69 and CD25 immunoreactivity was assessed by immunohistochemistry in 66 decidual samples derived from PA and from RPT.
RESULTS
RCAS1 immunoreactivity was statistically significantly higher in decidual tissue samples derived from patients with RPT than in those derived from patients with PA. A statistically significantly lower number of CD56(+) and CD3(+) cells and immunoreactivity level of CD69 were found in patients with RPT, compared to those with PA.
CONCLUSION
Placental abruption seems to be associated with excessive accumulation and activity of CD3(+) and CD56(+) cells in decidua, which processes might, in turn, result from an insufficient RCAS1 decidual level.
问题
RCAS1是一种在妊娠期负责抑制细胞毒性免疫反应的蛋白质。本研究评估了胎盘早剥（PA）和胎盘组织残留（RPT）期间，RCAS1相对于免疫细胞状态的免疫反应水平。
研究方法
采用免疫组织化学法评估了66份来自PA和RPT的蜕膜样本中RCAS1、CD3、CD56、CD69和CD25的免疫反应性。
结果
RPT患者的蜕膜组织样本中RCAS1免疫反应性在统计学上显著高于PA患者。与PA患者相比，RPT患者中CD56(+)和CD3(+)细胞数量在统计学上显著减少，且CD69免疫反应水平降低。
结论
胎盘早剥似乎与蜕膜中CD3(+)和CD56(+)细胞的过度积累和活性有关，而这些过程可能反过来是由于蜕膜中RCAS1水平不足所致。
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