剖宫产术中患者免疫耐受水平与随后围产期紧急子宫切除术发生率之间的可能相关性。
The possible correlation between the patient's immune tolerance level during cesaerean section and the incidence of subsequent emergency peripartum hysterectomy.
作者信息
Wicherek Lukasz, Galazka Krystna
机构信息
Department of Gynecology, Obstetrics and Oncology, Jagiellonian University, 23 Kopernik Street, 31-501 Krakow, Poland.
出版信息
Clin Dev Immunol. 2007;2007:63596. doi: 10.1155/2007/63596.
INTRODUCTION
Cesarean section is an independent risk factor for peripartum hysterectomy. As a method of delivery, cesarean section may interfere with a number of molecular changes that occur at the maternal-fetal interface during the course of labor.
METHODS
The level of CD3, CD56, CD25, and CD69 antigen immunoreactivity was assessed by immunohistochemistry in 26 decidual tissue samples. The tissue samples were obtained from 18 women who underwent cesarean sections at term and from 8 women who underwent cesarean hysterectomies.
RESULTS
An increase in the activity and infiltration of immune cells in the decidua sampled during the spontaneous beginning of labor was observed. The further progression of labor was accompanied by a decrease in the number and activity of immune cells. The number of CD56+ and CD3+ cells in the decidua was statistically significantly lower in patients who had undergone cesarean hysterectomies than in those who had had cesarean sections at term.
CONCLUSION
Abnormal immune response during labor may increase the risk for peripartum hysterectomy.
引言
剖宫产是围产期子宫切除术的一个独立危险因素。作为一种分娩方式，剖宫产可能会干扰分娩过程中母胎界面发生的一些分子变化。
方法
通过免疫组织化学评估26份蜕膜组织样本中CD3、CD56、CD25和CD69抗原的免疫反应水平。组织样本取自18名足月行剖宫产的妇女和8名行剖宫产子宫切除术的妇女。
结果
观察到在自然分娩开始时取样的蜕膜中免疫细胞的活性和浸润增加。分娩的进一步进展伴随着免疫细胞数量和活性的降低。行剖宫产子宫切除术的患者蜕膜中CD56+和CD3+细胞的数量在统计学上显著低于足月行剖宫产的患者。
结论
分娩期间异常的免疫反应可能会增加围产期子宫切除术的风险。
Zotero 插件